Conopeptides as novel options for pain management

Daly, N. L. and Craik, David J. (2011) Conopeptides as novel options for pain management. Drugs of the Future, 36 1: 25-32. doi:10.1358/dof.2011.36.1.1561066

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Author Daly, N. L.
Craik, David J.
Title Conopeptides as novel options for pain management
Journal name Drugs of the Future   Check publisher's open access policy
ISSN 0377-8282
Publication date 2011-01
Sub-type Article (original research)
DOI 10.1358/dof.2011.36.1.1561066
Volume 36
Issue 1
Start page 25
End page 32
Total pages 8
Place of publication Barcelona, Spain
Publisher Prous Science
Collection year 2012
Language eng
Abstract Conopeptides are the peptidic components of the venoms of marine cone snails from the Conus genus. Aside from their natural function in pharmacologically immobilizing prey, they have attracted the attention of drug designers in recent years because of their potency and selectivity at a range of pharmaceutically important targets in mammals, including ion channels and neurotransmitter transporters. One conopeptide, MVIIA (ziconotide, Prialt®), is on the market for the treatment of intractable neuropathic pain and others are in preclinical or clinical development. This article provides an overview of recent developments in the conopeptide field, with particular reference to their potential applications as drugs for the treatment of pain.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 13 Oct 2011, 16:44:27 EST by Professor David Craik on behalf of School of Biomedical Sciences