Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy

Dang, Xin, Bialasiewicz, Seweryn, Nissen, Michael D., Sloots, Theo P., Koralnik, Igor J. and Tan, Chen S. (2011) Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PLoS One, 6 3: e16736.1-e16736.5. doi:10.1371/journal.pone.0016736

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Author Dang, Xin
Bialasiewicz, Seweryn
Nissen, Michael D.
Sloots, Theo P.
Koralnik, Igor J.
Tan, Chen S.
Title Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-03-16
Sub-type Article (original research)
DOI 10.1371/journal.pone.0016736
Open Access Status DOI
Volume 6
Issue 3
Start page e16736.1
End page e16736.5
Total pages 5
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2012
Language eng
Abstract Conflicting prevalence of newly identified KI(KIPyV), WU(WUPyV) and Merkel Cell Carcinoma(MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy(PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence of these polyomaviruses in cerebrospinal fluid(CSF), peripheral blood mononuclear cells(PBMC), and bone marrow samples from PML patients, immunosuppressed individuals with or without HIV, and multiple sclerosis(MS) patients. Distinct PCR tests for KIPyV, WUPyV and MCPyV DNA performed in two independent laboratories detected low levels of MCPyV DNA only in 1/269 samples. The infrequent detections of these viruses in multiple samples from immunosuppressed individuals including those with PML suggest that their reactivation mechanisms may be different from that of JC polyomavirus (JCPyV) and that they do not play a role in the pathogenesis of PML.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
Clinical Medical Virology Centre Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Oct 2011, 01:42:45 EST by Seweryn Bialasiewicz on behalf of Clinical Medical Virology Centre