Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity

Dutertre, Sebastien, Biass, Daniel, Stocklin, Reto and Favreau, Philippe (2010) Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity. Toxicon, 55 8: 1453-1462. doi:10.1016/j.toxicon.2010.02.025


Author Dutertre, Sebastien
Biass, Daniel
Stocklin, Reto
Favreau, Philippe
Title Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity
Formatted title
Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
1879-3150
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2010.02.025
Volume 55
Issue 8
Start page 1453
End page 1462
Total pages 10
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
With the advent of highly sensitive mass spectrometry techniques, the minute amount of various secretions produced by living animals can be studied to a level of details never attained before. In this study, we used LC-ESI-MS to analyse the injected venom of an indo-pacific piscivorous cone snail, Conus consors. While long-term follow up of several captive specimens have revealed a typical “venom fingerprint” for this species, dramatic variations were also observed. In the most extreme case, a single cone snail unexpectedly produced two very distinct venom profiles containing completely different sets of peptides with no overlap of detected masses. Surprisingly, there was no correlation between the peptides produced in the venom duct and those obtained after milking live cone snails, implying yet unknown mechanisms of selection and regulation. Our study defines the notion of intraspecimen variation and demonstrates how this phenomenon contributes to the overall venom diversity.
Keyword Venom
Conopeptide
Conus consors
Mass spectrometry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 13 Oct 2011, 13:50:36 EST by Mr Sebastien Dutertre on behalf of Institute for Molecular Bioscience