Venom peptide modulators of the immune system

Inserra, Marco C. and Lewis, Richard J. (2011) Venom peptide modulators of the immune system. Inflammation and Allergy - Drug Targets, 10 5: 399-410.

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Author Inserra, Marco C.
Lewis, Richard J.
Title Venom peptide modulators of the immune system
Journal name Inflammation and Allergy - Drug Targets   Check publisher's open access policy
ISSN 1871-5281
2212-4055
Publication date 2011-10-01
Sub-type Article (original research)
Volume 10
Issue 5
Start page 399
End page 410
Total pages 12
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Abstract Venomous animals produce a diverse range of peptides and small molecules that are of both therapeutic and pharmacologic value. One such animal, the cone snail, produces peptides known as conotoxins, which may be of interest to those studying the mammalian immune system. Conotoxins are a family of venom peptides that display extraordinary diversity and often exquisite specificity for membrane protein targets, especially voltage and ligand activated ion channels. Conopeptides are proving to be important pharmacological tools to probe human physiology, with some showing promise as therapeutics for conditions such as neuropathic pain. The potential of these peptides to interact and modulate the human immune system has not been investigated despite literature suggesting that conotoxins could be valuable research tools and potential therapeutics in the area of immunology. Known pharmacological targets of conopeptides expressed by immunocompetent cells include voltage-gated potassium channel (Kv), voltage-gated calcium channel (Cav), nicotinic and acetylcholine receptors. In addition, the 5-HT3, GABAB and NMDA receptors that are not considered classic immunomodulators may play a secondary role in modulating immune responses. This review highlights venom peptides with the potential to act at immunological targets within the mammalian immune system.
Keyword Cone snail
Contoxin
Conus
Immune system
N-methyl-D-aspartate
Neuronal nicotinic acetylcholine receptors
Potassium channels
Serotonin receptors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 13 Oct 2011, 22:02:36 EST by Richard Lewis on behalf of School of Public Health