Advances in resistive pulse sensors: Devices bridging the void between molecular and microscopic detection

Kozak, Darby, Anderson, Will, Vogel, Robert and Trau, Matt (2011) Advances in resistive pulse sensors: Devices bridging the void between molecular and microscopic detection. Nano Today, 6 5: 531-545.


Author Kozak, Darby
Anderson, Will
Vogel, Robert
Trau, Matt
Title Advances in resistive pulse sensors: Devices bridging the void between molecular and microscopic detection
Journal name Nano Today   Check publisher's open access policy
ISSN 1748-0132
1878-044X
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1016/j.nantod.2011.08.012
Volume 6
Issue 5
Start page 531
End page 545
Total pages 15
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2012
Language eng
Abstract Since the first reported use of a biological ion channel to detect differences in single stranded genomic base pairs in 1996, a renaissance in nanoscale resistive pulse sensors has ensued. This resurgence of a technique originally outlined and commercialized over 50 years ago has largely been driven by advances in nanoscaled fabrication, and ultimately, the prospect of a rapid and inexpensive means for genomic sequencing as well as other macromolecular characterization. In this pursuit, the potential application of these devices to characterize additional properties such as the size, shape, charge, and concentration of nanoscaled materials (10-900 nm) has been largely overlooked. Advances in nanotechnology and biotechnology are driving the need for simple yet sensitive individual object readout devices such as resistive pulse sensors. This review will examine the recent progress in pore-based sensing in the nanoscale range. A detailed analysis of three new types of pore sensors - in-series, parallel, and size-tunable pores - has been included. These pores offer improved measurement sensitivity over a wider particle size range. The fundamental physical chemistry of these techniques, which is still evolving, will be reviewed.
Keyword Coulter counter
Resistive pulse sensing
Nanopore
Pore sensor
Particle characterization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Issue section: "Reviews"

 
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Created: Wed, 12 Oct 2011, 18:34:11 EST by Dr Darby Kozak on behalf of School of Chemistry & Molecular Biosciences