Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats

Tan, Heok Yit, Rand, Jacquie S., Morton, John M., Fleeman, Linda M., Armstrong, P. Jane, Coradini, Marcia, Ishioka, Katsumi, Verkest, Kurt R., Richards, Ayanthi A., Rawlings, John M., Rose, Felicity J. and Whitehead, Jonathan P. (2011) Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats. General and Comparative Endocrinology, 172 3: 468-474. doi:10.1016/j.ygcen.2011.04.012


Author Tan, Heok Yit
Rand, Jacquie S.
Morton, John M.
Fleeman, Linda M.
Armstrong, P. Jane
Coradini, Marcia
Ishioka, Katsumi
Verkest, Kurt R.
Richards, Ayanthi A.
Rawlings, John M.
Rose, Felicity J.
Whitehead, Jonathan P.
Title Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats
Journal name General and Comparative Endocrinology   Check publisher's open access policy
ISSN 0016-6480
1095-6840
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1016/j.ygcen.2011.04.012
Volume 172
Issue 3
Start page 468
End page 474
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2012
Language eng
Formatted abstract
Adiponectin is a key adipokine that regulates carbohydrate and lipid metabolism. It circulates in stable low (LMW) and high molecular weight (HMW) forms. The aims of this study were to characterize baseline adiponectin profiles (total, LMW and HMW multimers) in healthy cats and to assess the effects of varying dietary carbohydrate content on adiponectin profiles. Cats were maintained on a diet with moderate carbohydrate content (37% metabolisable energy [ME]) for 4. weeks and then randomly allocated to either a low carbohydrate (19% ME) or high carbohydrate (52% ME) diet for 4. weeks. Fasting and postprandial plasma adiponectin profiles were measured by ELISA and sucrose gradient/Western blot. After consuming the moderate carbohydrate diet for 4. weeks, fasting total, HMW and LMW plasma adiponectin concentrations were 5.0 ± 0.6, 2.5 ± 0.5 and 2.6 ± 0.2 μg/mL, respectively. After changing to the low carbohydrate diet, fasting total adiponectin was unchanged but HMW adiponectin increased and LMW adiponectin decreased. No significant postprandial changes were observed. Cats consuming the high carbohydrate diet had increased fasting total and LMW adiponectin with no change in HMW adiponectin. In the postprandial state total adiponectin was reduced and there was a trend towards a decrease in HMW (p= 0.086) but not LMW multimers. These data indicate that feline adiponectin multimer profiles are similar to those reported in other species and demonstrate that changes in plasma adiponectin occur in response to chronic and acute carbohydrate intake and these reflect differential changes in adiponectin multimers.
Keyword Adipokine
Diet
Fasting
Postprandial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Veterinary Science Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 12 Oct 2011, 11:08:51 EST by Professor Jacquie Rand on behalf of School of Veterinary Science