A magnetic resonance imaging-based workflow for planning radiation therapy for prostate cancer

Greer, Peter B., Dowling, Jason A., Lambert, Jonathon A., Fripp, Jurgen, Parker, Joel, Denham, James W., Wratten, Chris, Capp, Anne and Salvado, Olivier (2011) A magnetic resonance imaging-based workflow for planning radiation therapy for prostate cancer. Medical Journal of Australia, 194 4: S24-S27.

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Author Greer, Peter B.
Dowling, Jason A.
Lambert, Jonathon A.
Fripp, Jurgen
Parker, Joel
Denham, James W.
Wratten, Chris
Capp, Anne
Salvado, Olivier
Title A magnetic resonance imaging-based workflow for planning radiation therapy for prostate cancer
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2011-02
Sub-type Article (original research)
Volume 194
Issue 4
Start page S24
End page S27
Total pages 4
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing Company
Collection year 2012
Language eng
Formatted abstract
• Dose planning for prostate radiation therapy is performed using computed tomography (CT) scans that provide the electron density information needed for individual patients’ radiation dose calculations.

• For visualising the prostate and determining the target volume for radiation treatment, magnetic resonance imaging (MRI) gives vastly superior soft-tissue contrast. However, currently, MRI scans cannot be used for dose planning, as they do not provide the electron density information.

• We aimed to develop an alternative and efficient MRI-only image-based workflow, enabling both organ delineation and dose planning to be performed using MRI, with “pseudo-CT scans” generated from MRI scans supplying the information for dose planning.

• The feasibility of implementing MRI-based prostate radiation therapy planning is being investigated through collaboration between the clinical and medical physics group at the Calvary Mater Newcastle Hospital/University of Newcastle and the biomedical imaging processing group at the CSIRO (Commonwealth Scientific and Industrial Research Organisation) Australian e-Health Research Centre

• Results comparing Hounsfield units calculated from CT scans and from MRI-based  pseudo-CT scans for 39 patients showed very similar average values for the prostate, bladder, bones and rectum, confirming that pseudo-CT scans can replace CT scans for accurate radiation dose calculations.

• MRI-based radiotherapy planning can also be used for tumours in other locations, such as head and neck, and breast cancers.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Centre for Advanced Imaging Publications
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