Estimating the burden of disease attributable to high cholesterol in South Africa in 2000

Norman, Rosana, Bradshaw, Debbie, Steyn, Krisela, Gaziano, Thomas and South African Comparative Risk Ass (2007) Estimating the burden of disease attributable to high cholesterol in South Africa in 2000. SAMJ South African Medical Journal, 97 8 Part 2: 708-715.

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Author Norman, Rosana
Bradshaw, Debbie
Steyn, Krisela
Gaziano, Thomas
South African Comparative Risk Ass
Title Estimating the burden of disease attributable to high cholesterol in South Africa in 2000
Journal name SAMJ South African Medical Journal   Check publisher's open access policy
ISSN 0256-9574
Publication date 2007-08
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 97
Issue 8 Part 2
Start page 708
End page 715
Total pages 8
Place of publication Claremont, South Africa
Publisher Health and Medical Publishing Group
Language eng
Formatted abstract
To estimate the burden of disease attributable to high cholesterol in adults aged 30 years and older in South Africa in 2000.

World Health Organization comparative risk assessment (CRA) methodology was followed. Small community studies were used to derive the prevalence by population group. Population-attributable fractions were calculated and applied to revised burden of disease estimates for the relevant disease categories for each population group. The total attributable burden for South Africa in 2000 was obtained by adding the burden attributed to high cholesterol for the four population groups. Monte Carlo simulation-modelling techniques were used for uncertainty analysis.


South Africa.


Black African, coloured, white and Indian adults aged 30 years and older.

Outcome measures.
Mortality and disability-adjusted life years (DALYs) from ischaemic heart disease (IHD) and ischaemic stroke.

Overall, about 59% of IHD and 29% of ischaemic stroke burden in adult males and females (30+ years) were attributable to high cholesterol (≥ 3.8 mmol/l), with marked variation by population group. High cholesterol was estimated to have caused 24 144 deaths (95% uncertainty interval 22 404 - 25 286) or 4.6% (95% uncertainty interval 4.3 - 4.9%) of all deaths in South Africa in 2000. Since most cholesterol-related cardiovascular disease events occurred in middle or old age, the loss of life years comprised a smaller proportion of the total: 222 923 DALYs (95% uncertainty interval 206 712 - 233 460) or 1.4% of all DALYs (95% uncertainty interval 1.3 - 1.4%) in South Africa in 2000.

High cholesterol is an important cardiovascular risk factor in all population groups in South Africa.
Keyword Coronary Heart-Disease
Antiretroviral Therapy
Cape Peninsula
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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