Plasma interleukin-12 in malaria-tolerant Papua New Guineans: Inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity

Boutlis, Craig S., Lagog, Moses, Chaisavaneeyakorn, Sujittra, Misukonis, Mary A., Bockarie, Moses J., Mgone, Charles S., Wang, Zhiqiang, Morahan, Grant, Weinberg, J. Brice, Udhayakumar, Venkatachalam and Anstey, Nicholas M. (2003) Plasma interleukin-12 in malaria-tolerant Papua New Guineans: Inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. Infection and Immunity, 71 11: 6354-6357. doi:10.1128/IAI.71.11.6354-6357.2003

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Author Boutlis, Craig S.
Lagog, Moses
Chaisavaneeyakorn, Sujittra
Misukonis, Mary A.
Bockarie, Moses J.
Mgone, Charles S.
Wang, Zhiqiang
Morahan, Grant
Weinberg, J. Brice
Udhayakumar, Venkatachalam
Anstey, Nicholas M.
Title Plasma interleukin-12 in malaria-tolerant Papua New Guineans: Inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity
Formatted title
Plasma interleukin-12 in malaria-tolerant Papua New Guineans: Inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2003-11
Sub-type Article (original research)
DOI 10.1128/IAI.71.11.6354-6357.2003
Open Access Status File (Publisher version)
Volume 71
Issue 11
Start page 6354
End page 6357
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. To better define the relationships between IL-12, NO, malaria parasitemia, and IL12B polymorphisms during malarial tolerance, plasma IL-12 levels and peripheral blood mononuclear cell NO synthase (NOS) activity were measured in asymptomatic Papua New Guineans exposed to intense malaria transmission. The IL-12 level was strongly inversely correlated with the density of Plasmodium falciparum parasitemia (ρ = −0.45; P < 0.001) and was predicted to decrease by 19% (95% confidence interval [CI], 10 to 27%) for each twofold increase in P. falciparum parasitemia. This is consistent with a suppressive effect of parasitemia on IL-12 production, an effect previously shown in vitro and in rodent models of disease. The IL-12 level was inversely correlated with NOS activity (r = −0.22; P = 0.007), with each twofold increase in NOS activity being predictive of a 25% (95% CI, 7 to 38%) decrease in plasma IL-12 levels. This probably reflects additional down-regulation of IL-12 by the high basal NO production and monocyte NOS expression found in the malaria-tolerant state. Neither the IL-12 level nor NOS activity was associated with either of two IL12B polymorphisms, reflecting the diversity of genetic control over immune responses in different populations.
Keyword Cytokine Production
Il-12
Immunity
Severity
Children
Suppression
Macrophages
Monocytes
Chabaudi
Disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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