Endotoxin signal transduction in macrophages

Sweet, M. J. and Hume, D. A. (1996) Endotoxin signal transduction in macrophages. Journal of Leukocyte Biology, 60 1: 8-26.

Author Sweet, M. J.
Hume, D. A.
Title Endotoxin signal transduction in macrophages
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
1938-3673
Publication date 1996-07
Sub-type Article (original research)
Volume 60
Issue 1
Start page 8
End page 26
Total pages 19
Place of publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Language eng
Abstract Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell surface to the nucleus. The involvement of protein tyrosine kinases, mitogen-activated protein kinases, protein kinase C, G proteins, protein kinase A, ceramide-activated protein kinase, and microtubules in this process are reviewed. At the nuclear level, rel, C/EBP, Ets, Egr, fos, and jun family members have been implicated in activation of LPS-inducible gene expression.
Keyword Ets
Lipopolysaccharide
NF-κB
NF-IL6
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Tue, 11 Oct 2011, 14:08:56 EST by Matt Sweet on behalf of School of Chemistry & Molecular Biosciences