Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid

Guzman, Carlos A., Molinari, Gabriella, Fountain, Michael W., Rohde, Manfred, Timmis, Kenneth N. and Walker, Mark J. (1993) Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid. Infection and Immunity, 61 2: 573-579.

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Author Guzman, Carlos A.
Molinari, Gabriella
Fountain, Michael W.
Rohde, Manfred
Timmis, Kenneth N.
Walker, Mark J.
Title Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 1993-02
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 61
Issue 2
Start page 573
End page 579
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Mice were orally vaccinated with liposomes coated with filamentous hemagglutinin (FHA) and detoxified pertussis toxin (PT) of Bordetella pertussis. FHA- and PT-specific immunoglobulin G (IgG) was detected in serum, and both IgG and IgA were detected in lung washes following the immunization. Antibody responses in mice immunized with liposomes coated with FHA and PT were significantly higher than those in mice immunized with free FHA and PT, which demonstrated the adjuvanticity of the liposome carrier. The results indicate the potential usefulness of this approach for eliciting immune responses against FHA and PT (and perhaps other pertussis antigens) in humans and its possible utility in large-scale vaccination to protect against both B. pertussis infection and disease.
Keyword Salmonella-Typhimurium Aroa
Major Antigen-Liposomes
Outer-Membrane Protein
Bordetella-Pertussis
Cutaneous Leishmaniasis
Immune-Response
Immunological Adjuvants
Monoclonal-Antibodies
Escherichia-Coli
Infection Model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Microscopy and Microanalysis Publications
 
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