Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

Walker, Mark J., McArthur, Jason D., McKay, Fiona and Ranson, Marie (2005) Is plasminogen deployed as a Streptococcus pyogenes virulence factor?. Trends in Microbiology, 13 7: 308-313. doi:10.1016/j.tim.2005.05.006


Author Walker, Mark J.
McArthur, Jason D.
McKay, Fiona
Ranson, Marie
Title Is plasminogen deployed as a Streptococcus pyogenes virulence factor?
Formatted title
Is plasminogen deployed as a Streptococcus pyogenes virulence factor?
Journal name Trends in Microbiology   Check publisher's open access policy
ISSN 0966-842X
1878-4380
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1016/j.tim.2005.05.006
Volume 13
Issue 7
Start page 308
End page 313
Total pages 6
Language eng
Formatted abstract
Streptococcus pyogenes (group A streptococcus) causes human skin and throat infections as well as highly invasive diseases including necrotizing fasciitis. Group A streptococcal infections and invasive disease have made a resurgence in developed countries during the past two decades. S. pyogenes use multiple pathways for the acquisition and activation of human plasminogen, securing potent proteolytic activity on the bacterial cell surface. Recent experimental evidence using a humanized transgenic mouse model suggests a crucial role for human plasminogen in the dissemination of S. pyogenes in vivo.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published under Opinion

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Chemistry and Molecular Biosciences
 
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