On the venom system of centipedes (Chilopoda), a neglected group of venomous animals

Undheim, Eivind A. B. and King, Glenn F. (2011) On the venom system of centipedes (Chilopoda), a neglected group of venomous animals. Toxicon, 57 4: 512-524. doi:10.1016/j.toxicon.2011.01.004

Author Undheim, Eivind A. B.
King, Glenn F.
Title On the venom system of centipedes (Chilopoda), a neglected group of venomous animals
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2011-03-15
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2011.01.004
Volume 57
Issue 4
Start page 512
End page 524
Total pages 13
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2012
Language eng
Abstract Centipedes are among the oldest extant terrestrial arthropods and are an ecologically important group of soil and leaf litter predators. Despite their abundance and frequent, often painful, encounters with humans, little is known about the venom and venom apparatus of centipedes, although it is apparent that these are both quite different from other venomous lineages. The venom gland can be regarded as an invaginated cuticle and epidermis, consisting of numerous epithelial secretory units each with its own unique valve-like excretory system. The venom contains several different enzymes, but is strikingly different to most other arthropods in that metalloproteases appear to be important. Myotoxic, cardiotoxic, and neurotoxic activities have been described, most of which have been attributed to high molecular weight proteins. Neurotoxic activities are also unusual in that G-protein coupled receptors often seem to be involved, either directly as targets of neurotoxins or indirectly by activating endogenous agonists. These relatively slow responses may be complemented by the rapid effects caused by histamines present in the venom and from endogenous release of histamines induced by venom cytotoxins. The differences probably reflect the ancient and independent evolutionary history of the centipede venom system, although they may also be somewhat exaggerated by the paucity of information available on this largely neglected group.
Keyword Centipedes
Venom gland
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 07 Oct 2011, 13:57:03 EST by Professor Glenn King on behalf of School of Chemistry & Molecular Biosciences