Longitudinal Growth and Lung Function in Pediatric Non-Cystic Fibrosis Bronchiectasis What Influences Lung Function Stability?

Kapur, Nitin, Masters, Ian Brent and Chang, Anne B. (2010) Longitudinal Growth and Lung Function in Pediatric Non-Cystic Fibrosis Bronchiectasis What Influences Lung Function Stability?. Chest, 138 1: 158-164. doi:10.1378/chest.09-2932


Author Kapur, Nitin
Masters, Ian Brent
Chang, Anne B.
Title Longitudinal Growth and Lung Function in Pediatric Non-Cystic Fibrosis Bronchiectasis What Influences Lung Function Stability?
Journal name Chest   Check publisher's open access policy
ISSN 0012-3692
1931-3543
Publication date 2010-07-01
Sub-type Article (original research)
DOI 10.1378/chest.09-2932
Volume 138
Issue 1
Start page 158
End page 164
Total pages 7
Place of publication Northbrook, IL, United States
Publisher American College of Chest Physicians
Language eng
Formatted abstract
Background: Longitudinal FEV1 data in children with non-cystic fibrosis (non-CF) bronchiectasis (BE) are contradictory, and there are no multifactor data on the evolution of lung function and growth in this group. We longitudinally reviewed lung function and growth in children with non-CF BE and explored biologically plausible factors associated with changes in these parameters over time.
Methods: Fifty-two children with ≥ 3 years of lung function data were retrospectively reviewed. Changes in annual anthropometry and spirometry at year 3 and year 5 from baseline were analyzed. The impact of sex, age, cause, baseline FEV1, exacerbation frequency, radiologic extent, socioeconomic status, environmental tobacco smoke exposure, and period of diagnosis was evaluated.
Results: Over 3 years, the group mean forced expiratory flow midexpiratory phase percent predicted and BMI z-score improved by 3.01 (P = .04; 95% CI, 0.14-5.86) and 0.089 (P = .01; 95% CI, 0.02-0.15) per annum, respectively. FEV1% predicted, FVC% predicted, and height z-score all showed nonsignificant improvement. Over 5 years, there was improvement in FVC% predicted (slope 1.74; P = .001) annually, but only minor improvement in other parameters. Children with immunodeficiency and those with low baseline FEV1 had significantly lower BMI at diagnosis. Frequency of hospitalized exacerbation and low baseline FEV1 were the only significant predictors of change in FEV1 over 3 years. Decline in FEV1% predicted was large (but nonsignificant) for each additional year in age of diagnosis.
Conclusions: Spirometric and anthropometric parameters in children with non-CF BE remain stable over a 3- to 5-year follow-up period once appropriate therapy is instituted. Severe exacerbations result in accelerated lung function decline. Increased medical cognizance of children with chronic moist cough is needed for early diagnosis, better management, and improving overall outcome in BE.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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