Can a management pathway for chronic cough in children improve clinical outcomes: Protocol for a multicentre evaluation

Chang, A. B., Robertson, C. F., van Asperen, P. P., Glasgow, N. J., Masters, I. B., Mellis, C. M., Landau, L. I., Teoh, L. and Morris, P. S. (2010) Can a management pathway for chronic cough in children improve clinical outcomes: Protocol for a multicentre evaluation. Trials, 11 103.1-103.7. doi:10.1186/1745-6215-11-103


Author Chang, A. B.
Robertson, C. F.
van Asperen, P. P.
Glasgow, N. J.
Masters, I. B.
Mellis, C. M.
Landau, L. I.
Teoh, L.
Morris, P. S.
Title Can a management pathway for chronic cough in children improve clinical outcomes: Protocol for a multicentre evaluation
Journal name Trials   Check publisher's open access policy
ISSN 1745-6215
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1186/1745-6215-11-103
Open Access Status DOI
Volume 11
Start page 103.1
End page 103.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: Chronic cough is common and is associated with significant economic and human costs. While cough can be a problematic symptom without serious consequences, it could also reflect a serious underlying illness. Evidence shows that the management of chronic cough in children needs to be improved. Our study tests the hypothesis that the management of chronic cough in children with an evidence-based management pathway is feasible and reliable, and improves clinical outcomes.
Methods/Design: We are conducting a multicentre randomised controlled trial based in respiratory clinics in 5 major Australian cities. Children (n = 250) fulfilling inclusion criteria (new patients with chronic cough) are randomised (allocation concealed) to the standardised clinical management pathway (specialist starts clinical pathway within 2 weeks) or usual care (existing care until review by specialist at 6 weeks). Cough diary, cough-specific quality of life (QOL) and generic QOL are collected at baseline and at 6, 10, 14, 26, and 52 weeks. Children are followed-up for 6 months after diagnosis and cough resolution (with at least monthly contact from study nurses). A random sample from each site will be independently examined to determine adherence to the pathway. Primary outcomes are group differences in QOL and proportion of children that are cough free at week 6.
Discussion: The clinical management pathway is based on data from Cochrane Reviews combined with collective clinical experience (250 doctor years). This study will provide additional evidence on the optimal management of chronic cough in children.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article # 103

Document type: Journal Article
Sub-type: Article (original research)
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