Do sex and atopy influence cough outcome measurements in children?

Chang, Anne B., Gibson, Peter G., Willis, Carol, Petsky, Helen L., Widdicombe, John G., Masters, I. Brent and Robertson, Colin F. (2011) Do sex and atopy influence cough outcome measurements in children?. Chest, 140 2: 324-330.

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Author Chang, Anne B.
Gibson, Peter G.
Willis, Carol
Petsky, Helen L.
Widdicombe, John G.
Masters, I. Brent
Robertson, Colin F.
Title Do sex and atopy influence cough outcome measurements in children?
Journal name Chest   Check publisher's open access policy
ISSN 0012-3692
1931-3543
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1378/chest.10-2507
Volume 140
Issue 2
Start page 324
End page 330
Total pages 7
Place of publication Northbrook, IL, U.S.A.
Publisher American College of Chest Physicians
Collection year 2012
Language eng
Formatted abstract Background: Despite the commonality of cough and its burden, there are no published data on the relationship between atopy or sex on objectively measured cough frequency or subjective cough scores in children. In 202 children with and without cough, we determined the effect of sex and atopy on validated cough outcome measurements (cough receptor sensitivity [CRS], objective cough counts, and cough scores). We hypothesized that in contrast to adult data, sex does not influence cough outcome measures, and atopy is not a determinant of these cough measurements.

Methods: We combined data from four previous studies. Atopy (skin prick test), the concentration of capsaicin causing two and five or more coughs (C2 and C5, respectively), objectively measured cough frequency, and cough scores were determined and their relationship explored. The children’s (93 girls, 109 boys) mean age was 10.6 years (SD 2.9), and 56% had atopy.

Results:
In multivariate analysis, CRS was influenced by age (C2 coefficient, 5.9; P = .034; C5 coefficient, 29.1; P = .0001). Atopy and sex did not significantly influence any of the cough outcomes (cough counts, C2, C5, cough score) in control subjects and children with cough.

Conclusions:
Atopy does not influence important cough outcome measures in children with and without chronic cough. However, age, but not sex, influences CRS in children. Unlike adult data, sex does not affect objective counts or cough score in children with and without chronic cough. Studies on cough in children should be age matched, but matching for atopic status and sex is less important.
Keyword Quality-of-life
Receptor sensitivity
Recurrent cough
Bronchial responsiveness
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
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