The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice

Walker, Tara L., Turnbull, Geoff W., Mackay, Eirinn W., Hannan, Anthony J. and Bartlett, Perry F. (2011) The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice. PLoS One, 6 3: e18153-1-e18153-7. doi:10.1371/journal.pone.0018153

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Author Walker, Tara L.
Turnbull, Geoff W.
Mackay, Eirinn W.
Hannan, Anthony J.
Bartlett, Perry F.
Title The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-03-24
Sub-type Article (original research)
DOI 10.1371/journal.pone.0018153
Open Access Status DOI
Volume 6
Issue 3
Start page e18153-1
End page e18153-7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2012
Language eng
Formatted abstract
The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis. In this study we examined the effect of a progressive neurodegenerative condition on neural precursor activity in the subventricular zone (SVZ) and hippocampus of the R6/1 transgenic mouse model of Huntington's disease (HD). Our results revealed an age-related decline in SVZ precursor numbers in both wild-type (WT) and HD mice. Interestingly, hippocampal precursor numbers declined with age in WT mice, although we observed maintenance in hippocampal precursor number in the HD animals in response to advancement of the disease. This maintenance was consistent with activation of a recently identified latent hippocampal precursor population. We found that the small latent stem cell population was also maintained in the HD hippocampus at 33 weeks, whereas it was not present in the WT. Our findings demonstrate that, despite a loss of neurogenesis in the HD hippocampus in vivo, there is a unique maintenance of the precursor and stem cells, which may potentially be activated to ameliorate disease symptoms.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Wed, 05 Oct 2011, 14:44:16 EST by Debra McMurtrie on behalf of Queensland Brain Institute