Oncostatin M regulates neural precursor activity in the adult brain

Beatus, Paul, Jhaveri, Dhanisha J., Walker, Tara L., Lucas, Peter G., Rietze, Rodney L., Cooper, Helen M., Morikawa, Yoshihiro and Bartlett, Perry F. (2011) Oncostatin M regulates neural precursor activity in the adult brain. Developmental Neurobiology, 71 7: 619-633. doi:10.1002/dneu.20871

Author Beatus, Paul
Jhaveri, Dhanisha J.
Walker, Tara L.
Lucas, Peter G.
Rietze, Rodney L.
Cooper, Helen M.
Morikawa, Yoshihiro
Bartlett, Perry F.
Title Oncostatin M regulates neural precursor activity in the adult brain
Journal name Developmental Neurobiology   Check publisher's open access policy
ISSN 0022-3034
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1002/dneu.20871
Volume 71
Issue 7
Start page 619
End page 633
Total pages 15
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
The regulation of neural precursor cell (NPC) activity is the major determinant of the rate of neuronal production in neurogenic regions of the adult brain. Here, we show that Oncostatin M (Osm) and its receptor, OsmRβ, are both expressed in the subventricular zone (SVZ) and that in contradistinction to leukemia inhibitory factor and ciliary neutrophic factor, Osm directly inhibits the proliferation of adult NPCs as measured by a decreased level of neurosphere formation in vitro. Similarly, intraventricular infusion of Osm dramatically decreases the pool of NPCs in both the SVZ and the hippocampus. In keeping with the inhibitory action of Osm, we reveal that mice lacking OsmRβ have substantially more NPCs in the SVZ, the hippocampus and the olfactory bulb, demonstrating that endogenous Osm signaling is important for NPC homeostasis. Finally, we show that Osm can also inhibit clonal growth of glioblastoma-derived neurospheres, further supporting the close link between NPCs and tumor stem cells.
Keyword Neural stem cells
Leukemia inhibitory factor
Mammalian forebrain
Matrix metalloproteinases
Growth arrest
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Wed, 05 Oct 2011, 14:25:49 EST by Debra McMurtrie on behalf of Queensland Brain Institute