Antimicrobial utilisation in 37 Australian and New Zealand intensive care units

Dulhunty, J. M., Paterson, D., Webb, S. A. R. and Lipman, J. (2011) Antimicrobial utilisation in 37 Australian and New Zealand intensive care units. Anaesthesia and Intensive Care, 39 2: 231-237.

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Author Dulhunty, J. M.
Paterson, D.
Webb, S. A. R.
Lipman, J.
Title Antimicrobial utilisation in 37 Australian and New Zealand intensive care units
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 2011-03
Sub-type Article (original research)
Volume 39
Issue 2
Start page 231
End page 237
Total pages 7
Place of publication Edgecliff, NSW, Australia
Publisher Australian Society of Anaesthetists
Collection year 2012
Language eng
Abstract This multi-centre point prevalence study reports on antimicrobial dosing patterns, including dose, mode of administration and type of infection, in 37 Australian and New Zealand intensive care units. Of 422 patients admitted to an intensive care unit on 8 May 2007, 195 patients (46%) received antimicrobial treatment, 123 patients (29%) received no antimicrobials and 104 patients (25%) received prophylactic antimicrobials only. Dosing data were available for 331 antimicrobials used to treat 225 infections in 193 patients. Respiratory (40%), abdominal (13%) and blood stream (12%) infections were most common. For adult patients, ticarcillin/clavulanate (23% or 40/177), meropenem (20% or 35/177) and vancomycin (18% or 32/177) were the most frequently used antibiotics; vancomycin was most commonly used in children (31% or 5/16). The majority of antimicrobials were administered as bolus doses or infusions of less than two hours (98% or 317/323); only six patients received extended or continuous infusions. The mode of administration was unknown in eight cases (4.1%). The total defined daily dose for adult patients receiving antimicrobial therapy was 2051 defined daily doses per 1000 patient days. Our results confirm that the use of continuous infusions remains rare, despite increased interest in continuous infusions for time-dependent antibiotics.
Keyword Antibiotic
Dosing patterns
Continuous infusions
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
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Created: Wed, 05 Oct 2011, 12:22:28 EST by Matthew Lamb on behalf of School of Medicine