Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series

Barwood, Caroline H. S., Murdoch, Bruce E., Whelan, Brooke-Mai, Lloyd, David, Riek, Stephan, O’Sullivan, John D., Coulthard, Alan and Wong, Andrew (2012) Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series. Brain Stimulation, 54 3: 274-286. doi:10.1016/j.brs.2011.03.005

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Coulthard_Alan_authaffil.pdf Coulthard_Alan_authaffil.pdf application/pdf 77.43KB 1
Coulthard_Alan_staffdata.pdf Coulthard_Alan_staffdata.pdf application/pdf 69.67KB 0
UQ253911_other.pdf UQ253911_other.pdf application/pdf 5.69KB 0
Wong_Andrew_authoraffil_staffdata.pdf Wong_Andrew_authoraffil_staffdata.pdf application/pdf 256.85KB 1

Author Barwood, Caroline H. S.
Murdoch, Bruce E.
Whelan, Brooke-Mai
Lloyd, David
Riek, Stephan
O’Sullivan, John D.
Coulthard, Alan
Wong, Andrew
Title Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series
Journal name Brain Stimulation   Check publisher's open access policy
ISSN 1935-861X
1876-4754
Publication date 2012-07
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.brs.2011.03.005
Volume 54
Issue 3
Start page 274
End page 286
Total pages 13
Place of publication Philadelphia, PA, U.S.A.
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Background: Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH.

Objective/Hypothesis
: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS.

Results: In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application.

Conclusions
: The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.
Keyword Stroke
Aphasia
Nonfluent aphasia
Language
Rehabilitation
Transcranial magnetic stimulation
rTMS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 13 April 2011.

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 03 Oct 2011, 12:00:38 EST by Matthew Lamb on behalf of School of Medicine