C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail

Hilliard, Massimo A., Bargmann, Cornelia I. and Bazzicalupo, Paolo (2002) C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail. Current Biology, 12 9: 730-734. doi:10.1016/S0960-9822(02)00813-8


Author Hilliard, Massimo A.
Bargmann, Cornelia I.
Bazzicalupo, Paolo
Title C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
1879-0445
Publication date 2002-04
Sub-type Article (original research)
DOI 10.1016/S0960-9822(02)00813-8
Volume 12
Issue 9
Start page 730
End page 734
Total pages 5
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract The phasmids are bilateral sensory organs located in the tail of Caenorhabditis elegans and other nematodes. The similar structures of the phasmids and the amphid chemosensory organs in the head have long suggested a chemosensory function for the phasmids [1]. However, the PHA and PHB phasmid neurons are not required for chemotaxis [2, 3] or for dauer formation [4], and no direct proof of a chemosensory function of the phasmids has been obtained. C. elegans avoids toxic chemicals by reversing its movement, and this behavior is mediated by sensory neurons of the amphid, particularly, the ASH neurons [5, 6]. Here we show that the PHA and PHB phasmid neurons function as chemosensory cells that negatively modulate reversals to repellents. The antagonistic activity of head and tail sensory neurons is integrated to generate appropriate escape behaviors: Detection of a repellent by head neurons mediates reversals, which are suppressed by antagonistic inputs from tail neurons. Our results suggest that C. elegans senses repellents by defining a head-to-tail spatial map of the chemical environment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 118 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 116 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 03 Oct 2011, 09:49:55 EST by Massimo Hilliard on behalf of Queensland Brain Institute