Identification of a naturally occurring quinazolin-4(3H)-one luciferase inhibitor

Somanadhan, Brinda, Leong, Chungyan, Whitton, Stephen R., Ng, Siewbee, Buss, Antony D. and Butler, Mark S (2011) Identification of a naturally occurring quinazolin-4(3H)-one luciferase inhibitor. Journal of Natural Products, 74 6: 1500-1502. doi:10.1021/np1006179


Author Somanadhan, Brinda
Leong, Chungyan
Whitton, Stephen R.
Ng, Siewbee
Buss, Antony D.
Butler, Mark S
Title Identification of a naturally occurring quinazolin-4(3H)-one luciferase inhibitor
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2011-06-24
Sub-type Article (original research)
DOI 10.1021/np1006179
Volume 74
Issue 6
Start page 1500
End page 1502
Total pages 3
Place of publication United States
Publisher American Chemical Society
Collection year 2012
Language eng
Abstract A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 30 Sep 2011, 16:44:09 EST by Mark Butler on behalf of Institute for Molecular Bioscience