Genome-wide association study identifies five new schizophrenia loci

Ripke, Stephan, Sanders, Alan R., Kedler, Kenneth S., Levinson, Douglas F., Sklar, Pamela, Holmans, Peter A., Lin, Dan-Yu, Duan, Jubao, Ophoff, Roel A., Andreassen, Ole A., Scolnick, Edward, Cichon, Sven, St. Clair, David, Corvin, Aiden, Gurling, Hugh, Werge, Thomas, Rujescu, Dan, Blackwood, Douglas H. R., Pato, Carlos N., Malhotra, Anil K., Purcell, Shaun, Dudbridge, Frank, Neale, Benjamin M., Rossin, Lizzy, Visscher, Peter M., Posthuma, Danielle, Ruderfer, Douglas M., Fanous, Ayman, Hreinn, Stefansson, Steinberg, Stacy, Mowry, Bryan J., Golimbet, Vera, De Hert, Marc, Jonsson, Erik G., Bitter, Istvan, Pietilainen, Olli P., Collier, David A., Tosato, Sarah, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amdur, Richard L., Amin, Farooq, Bass, Nicholas, Bergen, Sarah E., Black, Donald W., Borglum, Anders D., Brown, Matthew A., Bruggeman, Richard, Buccola, Nancy G., Byerley, William F., Cahn, Wiepke, Cantor, Rita M., Carr, Vaughan J., Catts, Stanley V., Choudhury, Khalid, Cloninger, C. Robert, Cormican, Paul, Craddock, Nicholas, Danoy, Patrick A., Datta, Susmita, de Haan, Lieuwe, Demontis, Ditte, Dikeos, Dimitris, Djurovic, Srdjan, Donnelly, Peter, Donohoe, Gary, Linh, Duong, Dwyer, Sarah, Fink-Jensen, Anders, Freedman, Robert, Freimer, Nelson B., Friedle, Marion, Georgieva, Lyudmila, Giegling, Ina, Gill, Michael, Clenthoj, Birte, Godard, Stephanie, Hamshere, Marian, Hansen, Mark, Hansen, Thomas, Hartmann, Annette M., Henskens, Frans A., Hougaard, David M., Hultman, Christina M., Ingason, Andres, Jablensky, Assen V., Jakobsen, Klaus D., Jay, Maurice, Jurgens, Gesche, Kahn, Rene S., Keller, Matthew C., Kenis, Gunter, Kenny, Elaine, Kim, Yunjung, Kirov, George K., Konnerth, Heike, Konte, Bettina, Krabbendam, Lydia, Krasucki, Robert, Lasseter, Virginia K., Laurent, Claudine, Lawrence, Jacob, Lencz, Todd, Lerer, F. Bernhard, Liang, Kung-Yee, Lichtenstein, Paul, Liebermann, Jeffrey A., Linszen, Don H., Lonnqvist, Jouko, Loughland, Carmel M., Maclean, Alan W., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Malloy, Pat, Mattheisen, Manuel, Mattingsdal, Morten, McGhee, Kevin A., McGrath, John J., McIntosh, Andrew, McLean, Duncan E., McQuillin, Andrew, Melle, Ingrid, Michie, Patricia T., Milanova, Vihra, Morris, Derek W., Mors, Ole, Mortensen, Preben B., Moskvina, Valentina, Muglia, Pierandrea, Myin-Germeys, Inez, Nertney, Deborah A., Nestadt, Gerald, Nielsen, Jimmi, Nikolov, Ivan, Nordentoft, Merete, Norton, Nadine, Nothen, Markus M., O'Dushlaine, Colm T., Olincy, Ann, Olsen, Line, O'Neill, F. Anthony, Orntoft, Torben F., Owen, Michael J., Pantelis, Christos, Papadimitriou, George, Pato, Michele T., Peltonen, Leena, Petursson, Hannes, Pickard, Ben, Pimm, Jonathan, Pulver, Ann E., Puri, Vinay, Quested, Digby, Quinn, Emma M., Rasmussen, Henrik B., Rethelyi, Janos M., Ribble, Robert, Rietschel, Marcella, Riley, Brien P., Ruggeri, Mirella, Schall, Ulrich, Schulze, Thomas G., Schwab, Sibylle G., Scott, Rodney J., Shi, Jianxin, Sigurdson, Engilbert, Silverman, Jeremy M., Spencer, Chris C. A., Stefansson, Kari, Strange, Amy, Strengman, Eric, Stroup, T. Scott, Suvisaari, Jaana, Terenius, Lars, Thirumalai, Srinivasa, Thygesen, Johan H., Timm, Sally, Toncheva, Draga, van den Oord, Edwin, van Os, Jim, van Winkel, Ruud, Veldink, Jan, Walsh, Dermot, Wang, August G., Wiesrma, Durk, Wildenauer, Dieter B., Williams, Hywel J., Williams, Nigel M., Wormley, Brandon, Zammitt, Stan, Sullivan, Patrick F., O'Donovan, Micahel C., Daly, Mark J. and Gejman, Pablo V. (2011) Genome-wide association study identifies five new schizophrenia loci. Nature Genetics, 43 10: 969-976. doi:10.1038/ng.940


Author Ripke, Stephan
Sanders, Alan R.
Kedler, Kenneth S.
Levinson, Douglas F.
Sklar, Pamela
Holmans, Peter A.
Lin, Dan-Yu
Duan, Jubao
Ophoff, Roel A.
Andreassen, Ole A.
Scolnick, Edward
Cichon, Sven
St. Clair, David
Corvin, Aiden
Gurling, Hugh
Werge, Thomas
Rujescu, Dan
Blackwood, Douglas H. R.
Pato, Carlos N.
Malhotra, Anil K.
Purcell, Shaun
Dudbridge, Frank
Neale, Benjamin M.
Rossin, Lizzy
Visscher, Peter M.
Posthuma, Danielle
Ruderfer, Douglas M.
Fanous, Ayman
Hreinn, Stefansson
Steinberg, Stacy
Mowry, Bryan J.
Golimbet, Vera
De Hert, Marc
Jonsson, Erik G.
Bitter, Istvan
Pietilainen, Olli P.
Collier, David A.
Tosato, Sarah
Agartz, Ingrid
Albus, Margot
Alexander, Madeline
Amdur, Richard L.
Amin, Farooq
Bass, Nicholas
Bergen, Sarah E.
Black, Donald W.
Borglum, Anders D.
Brown, Matthew A.
Bruggeman, Richard
Buccola, Nancy G.
Byerley, William F.
Cahn, Wiepke
Cantor, Rita M.
Carr, Vaughan J.
Catts, Stanley V.
Choudhury, Khalid
Cloninger, C. Robert
Cormican, Paul
Craddock, Nicholas
Danoy, Patrick A.
Datta, Susmita
de Haan, Lieuwe
Demontis, Ditte
Dikeos, Dimitris
Djurovic, Srdjan
Donnelly, Peter
Donohoe, Gary
Linh, Duong
Dwyer, Sarah
Fink-Jensen, Anders
Freedman, Robert
Freimer, Nelson B.
Friedle, Marion
Georgieva, Lyudmila
Giegling, Ina
Gill, Michael
Clenthoj, Birte
Godard, Stephanie
Hamshere, Marian
Hansen, Mark
Hansen, Thomas
Hartmann, Annette M.
Henskens, Frans A.
Hougaard, David M.
Hultman, Christina M.
Ingason, Andres
Jablensky, Assen V.
Jakobsen, Klaus D.
Jay, Maurice
Jurgens, Gesche
Kahn, Rene S.
Keller, Matthew C.
Kenis, Gunter
Kenny, Elaine
Kim, Yunjung
Kirov, George K.
Konnerth, Heike
Konte, Bettina
Krabbendam, Lydia
Krasucki, Robert
Lasseter, Virginia K.
Laurent, Claudine
Lawrence, Jacob
Lencz, Todd
Lerer, F. Bernhard
Liang, Kung-Yee
Lichtenstein, Paul
Liebermann, Jeffrey A.
Linszen, Don H.
Lonnqvist, Jouko
Loughland, Carmel M.
Maclean, Alan W.
Maher, Brion S.
Maier, Wolfgang
Mallet, Jacques
Malloy, Pat
Mattheisen, Manuel
Mattingsdal, Morten
McGhee, Kevin A.
McGrath, John J.
McIntosh, Andrew
McLean, Duncan E.
McQuillin, Andrew
Melle, Ingrid
Michie, Patricia T.
Milanova, Vihra
Morris, Derek W.
Mors, Ole
Mortensen, Preben B.
Moskvina, Valentina
Muglia, Pierandrea
Myin-Germeys, Inez
Nertney, Deborah A.
Nestadt, Gerald
Nielsen, Jimmi
Nikolov, Ivan
Nordentoft, Merete
Norton, Nadine
Nothen, Markus M.
O'Dushlaine, Colm T.
Olincy, Ann
Olsen, Line
O'Neill, F. Anthony
Orntoft, Torben F.
Owen, Michael J.
Pantelis, Christos
Papadimitriou, George
Pato, Michele T.
Peltonen, Leena
Petursson, Hannes
Pickard, Ben
Pimm, Jonathan
Pulver, Ann E.
Puri, Vinay
Quested, Digby
Quinn, Emma M.
Rasmussen, Henrik B.
Rethelyi, Janos M.
Ribble, Robert
Rietschel, Marcella
Riley, Brien P.
Ruggeri, Mirella
Schall, Ulrich
Schulze, Thomas G.
Schwab, Sibylle G.
Scott, Rodney J.
Shi, Jianxin
Sigurdson, Engilbert
Silverman, Jeremy M.
Spencer, Chris C. A.
Stefansson, Kari
Strange, Amy
Strengman, Eric
Stroup, T. Scott
Suvisaari, Jaana
Terenius, Lars
Thirumalai, Srinivasa
Thygesen, Johan H.
Timm, Sally
Toncheva, Draga
van den Oord, Edwin
van Os, Jim
van Winkel, Ruud
Veldink, Jan
Walsh, Dermot
Wang, August G.
Wiesrma, Durk
Wildenauer, Dieter B.
Williams, Hywel J.
Williams, Nigel M.
Wormley, Brandon
Zammitt, Stan
Sullivan, Patrick F.
O'Donovan, Micahel C.
Daly, Mark J.
Gejman, Pablo V.
Title Genome-wide association study identifies five new schizophrenia loci
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1038/ng.940
Volume 43
Issue 10
Start page 969
End page 976
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10-11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10-9), ANK3 (rs10994359, P = 2.5 × 10-8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10-9).
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Created: Fri, 30 Sep 2011, 11:39:21 EST by Sheila Cleary on behalf of Psychiatry - Royal Brisbane and Women's Hospital