The emerging role of nuclear factor kappa B in renal cell carcinoma

Morais, Christudas, Gobe, Glenda, Johnson, David W. and Healy, Helen (2011) The emerging role of nuclear factor kappa B in renal cell carcinoma. International Journal of Biochemistry & Cell Biology, 43 11: 1537-1549. doi:10.1016/j.biocel.2011.08.003


Author Morais, Christudas
Gobe, Glenda
Johnson, David W.
Healy, Helen
Title The emerging role of nuclear factor kappa B in renal cell carcinoma
Journal name International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2011-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biocel.2011.08.003
Volume 43
Issue 11
Start page 1537
End page 1549
Total pages 13
Place of publication Oxford, England, U.K.
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
Renal cell carcinoma (RCC), the commonest type of kidney cancer, is a highly metastatic and the deadliest of all urologic cancers. Despite the development of many novel chemotherapeutics in recent years, metastatic RCC remains an incurable and lethal disease. The imperative for the identification of novel molecular targets and more effective therapeutics for metastatic RCC remain. One promising target is the transcription factor nuclear factor kappa B (NF-κB). NF-κB is unique in the sense that it regulates all important aspects of RCC biology that pose challenge to conventional therapy – resistance to apoptosis, angiogenesis and multi-drug resistance. Aberrations in the von Hippel Lindau gene (VHL) are the most important risk factor for the development of RCC, especially the clear cell type, which constitutes 70–80% of RCC. VHL is a negative regulator of NF-κB. In the absence of a functional VHL, the expression and activity of NF-κB are enhanced, which subsequently confer drug resistance and promote epithelial–mesenchymal-transition of RCC. This review provides an overview of RCC, its molecular mechanisms, the role of NF-κB in carcinomas including RCC, and the rationale for NF-κB as a target molecule.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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Created: Fri, 30 Sep 2011, 21:37:59 EST by Matthew Lamb on behalf of School of Medicine