LC/MS/MS analysis of the daphnane orthoester simplexin in poisonous Pimelea species of Australian rangelands

Fletcher, M. T., Chow, K. Y. S., Silcock, R. G. and Milson, J. A. (2011). LC/MS/MS analysis of the daphnane orthoester simplexin in poisonous Pimelea species of Australian rangelands. In Franklin Riet-Correa, Jim Pfister, Ana Lucia Schild and Terrie Wierenga (Ed.), Poisoning by plants, mycotoxins, and related toxins (pp. 550-556) Wallingford, England, U.K.: CAB International.

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Author Fletcher, M. T.
Chow, K. Y. S.
Silcock, R. G.
Milson, J. A.
Title of chapter LC/MS/MS analysis of the daphnane orthoester simplexin in poisonous Pimelea species of Australian rangelands
Formatted title
LC/MS/MS analysis of the daphnane orthoester simplexin in poisonous Pimelea species of Australian rangelands
Title of book Poisoning by plants, mycotoxins, and related toxins
Place of Publication Wallingford, England, U.K.
Publisher CAB International
Publication Year 2011
Sub-type Research book chapter (original research)
ISBN 9781845938338
1845938348
Editor Franklin Riet-Correa
Jim Pfister
Ana Lucia Schild
Terrie Wierenga
Chapter number 95
Start page 550
End page 556
Total pages 7
Total chapters 124
Collection year 2012
Language eng
Formatted Abstract/Summary
Pimelea species (also known as riceflowers) are ephemeral native plants found
throughout inland regions of Queensland (Qld), New South Wales (NSW), South Australia
(SA), and the Northern Territory (NT), extending over about one-quarter of Australia’s
pastoral lands. Three species of Pimelea (P. simplex, P. elongata, and P. trichostachya) are
poisonous to livestock and potentially fatal to cattle with serious economic consequences
through loss of production, stock deaths, and the costs of agistment. The associated
poisoning syndrome in cattle is unique to Australia and characterized by pulmonary venule
constriction leading to right ventricular dilation and subcutaneous edema of brisket and
head. Consumption of plant material can also lead to acute diarrhea in cattle and sheep.

Feeding trials in the early1970s established Pimelea spp. as the cause of this syndrome
(Clark 1971a, b, 1973; McClure and Farrow 1971) and the primary toxin was identified as
the novel daphnane orthoester simplexin 1 (Roberts et al. 1975; Freeman et al. 1979). A
number of compounds of related structure have also been isolated from these Pimelea
species including huratoxin 2 :650J2-acetoxyhuratoxin 3 (Zayed et al. 1977; Freeman et al.
1979; Hafez et al. 1983). However the incidence of poisoning remains difficult to predict
and there is a lack of clear understanding of why some properties or animals are affected by
Pimelea poisoning when others are not. In this study, liquid chromatography/mass
spectrometry/mass spectrometry (LC/MS/MS) analysis of more than 700 plant samples
enabled toxin levels to be related to plant species, stage of growth, and other environmental
factors to provide a sound basis for further epidemiological studies. [Introduction]
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes The chapters published in this book were presented at the 8th International Symposium on Poisonous Plants (ISOPP8) held in Joâo Pessoa, Brazil, May 2009.

 
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Created: Tue, 27 Sep 2011, 17:10:53 EST by Dr Mary Fletcher on behalf of School of Chemistry & Molecular Biosciences