Regioselective enzymatic acylation of N-acetylhexosamines

Simerská, Pavla, Pišvejcová, Andrea, Kuzma, Marek, Sedmera, Petr, Křen, Vladimır, Nicotra, Silvia and Riva, Sergio (2004) Regioselective enzymatic acylation of N-acetylhexosamines. Journal of Molecular Catalysis B: Enzymatic, 29 1-6: 219-225. doi:10.1016/j.molcatb.2003.10.018


Author Simerská, Pavla
Pišvejcová, Andrea
Kuzma, Marek
Sedmera, Petr
Křen, Vladimır
Nicotra, Silvia
Riva, Sergio
Title Regioselective enzymatic acylation of N-acetylhexosamines
Journal name Journal of Molecular Catalysis B: Enzymatic   Check publisher's open access policy
ISSN 1873-3158
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.molcatb.2003.10.018
Volume 29
Issue 1-6
Start page 219
End page 225
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
A careful choice of the reaction conditions (solvent, enzyme, acylating agent) allowed an efficient regioselective acylation of N-acetylhexosamines. 6-O-Acyl derivatives of 2-acetamido-2-deoxy-D-glucopyranose (GlcNAc), 2-acetamido-2-deoxy-D-galactopyranose (GalNAc) and 2-acetamido-2-deoxy-D- mannopyranose (ManNAc) have been isolated from regioselective esterifications catalysed by the protease subtilisin in CH3CN-DMSO 8:2 in good yields.
Keyword Enzymatic acylation
N-acetylhexosamines
Regioselectivity
Subtilisin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 28 Sep 2011, 02:46:55 EST by Dr Pavla Simerska on behalf of School of Chemistry & Molecular Biosciences