Anti-inflammatory, diuretic and antibacterial activities of aerial parts of Mucuna pruriens Linn

Bala, V., Debnath, A., Shill, A. K. and Bose, U. (2011) Anti-inflammatory, diuretic and antibacterial activities of aerial parts of Mucuna pruriens Linn. International Journal of Pharmacology, 7 4: 498-503. doi:10.3923/ijp.2011.498.503


Author Bala, V.
Debnath, A.
Shill, A. K.
Bose, U.
Title Anti-inflammatory, diuretic and antibacterial activities of aerial parts of Mucuna pruriens Linn
Formatted title
Anti-inflammatory, diuretic and antibacterial activities of aerial parts of Mucuna pruriens Linn
Journal name International Journal of Pharmacology   Check publisher's open access policy
ISSN 1811-7775
1812-5700
Publication date 2011-05
Sub-type Article (original research)
DOI 10.3923/ijp.2011.498.503
Open Access Status DOI
Volume 7
Issue 4
Start page 498
End page 503
Total pages 6
Place of publication Faisalabad, Pakistan
Publisher ANSI Network
Collection year 2012
Language eng
Formatted abstract
The ethanolic extract of the dried aerial parts of Mucuna pruriens Linn. (Fabaceae) was investigated for its possible anti-inflammatory, diuretic and antibacterial activities in animal models. Anti-inflammatory activity was tested using carrageenin induced rat paw edema model and cotton pellet implantation method in rat. Diuretic activity was measured by the comparison of control group, standard drug group (furosemide) at a dose of 0.5 mg kg-1 and the sample extracts 200 and 400 mg kg-1, respectively. The antibacterial property was studied by the disc diffusion method using extract 200 mg disc-1. The extracts significantly (p<0.001) reduced carrageenin induced paw edema in rats. Cotton pellet implantation model for antiinflammatory activity, the extract showed a significant reduction in the weight of the cotton pellet in test animal compared to control (p<0.001). At the doses of 200 and 400 mg kg-1, the extract exhibited 24.59 and 33.41% reduction of the weight of the cotton pellets. Diuretic activity was proved by the electrolyte loss ratio (Na+/K+ excretion ratio was 1.48 and 1.45 at the doses of 200 and 400 mg kg-1, respectively) as that of the standard diuretic furosemide (1.47). The extracts also showed the antibacterial activity against eight species of bacteria. The results obtained shows that the extracts of Mucuna pruriens Linn. has anti-inflammatory, diuretic and antibacterial properties. This finding provides a basis for the traditional use of the plant material.
Keyword Mucuna prurient Linn
Carrageenin
Cotton pellet granuloma
Furosemide
Disc diffusion
Ethanolic extract
Inflammatory response
Immune-response
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Pharmacy Publications
 
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