Vaccinomics for the major blood feeding helminths of humans

Loukas, Alex, Gaze, Soraya, Mulvenna, Jason P., Gasser, Robin B, Brindley, Paul J., Doolan, Denise L., Bethony, Jeffrey M., Jones, Malcolm K., Gobert, Geoffrey N., Driguez, Patrick, McManus, Donald P. and Hotez, Peter J. (2011) Vaccinomics for the major blood feeding helminths of humans. OMICS: A Journal of Integrative Biology, 15 9: 567-577. doi:10.1089/omi.2010.0150

Author Loukas, Alex
Gaze, Soraya
Mulvenna, Jason P.
Gasser, Robin B
Brindley, Paul J.
Doolan, Denise L.
Bethony, Jeffrey M.
Jones, Malcolm K.
Gobert, Geoffrey N.
Driguez, Patrick
McManus, Donald P.
Hotez, Peter J.
Title Vaccinomics for the major blood feeding helminths of humans
Journal name OMICS: A Journal of Integrative Biology   Check publisher's open access policy
ISSN 1536-2310
Publication date 2011-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1089/omi.2010.0150
Volume 15
Issue 9
Start page 567
End page 577
Total pages 11
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2012
Language eng
Formatted abstract
Approximately one billion people are infected with hookworms and/or blood flukes (schistosomes) in developing countries. These two parasites are responsible for more disability adjusted life years lost than most other neglected tropical diseases (NTDs), and together, are second only to malaria. Although anthelmintic drugs are effective and widely available, they do not protect against reinfection, resistant parasites are likely to emerge, and mass drug administration programs are unsustainable. Therefore, there is a pressing need for the development of vaccines against these parasites. In recent years, there have been major advances in our understanding of hookworms and schistosomes at the molecular level through the use of "omics" technologies. The secretomes of these parasites have been characterized using transcriptomics, genomics, proteomics, and newly developed gene manipulation and silencing techniques, and the proteins of interest are now the target of novel antigen discovery approaches, notably immunomics. This research has resulted in the discovery, development, and early stage clinical trials of subunit vaccines against hookworms and schistosomes.
Keyword Laser Microdissection Microscopy
Fluke Schistosoma-Mansoni
Lung-Stage Larvae
Rna Interference
Hookworm Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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