Carbohydrates as scaffolds in drug discovery

Meutermans, Wim, Le, Giang Thanh and Becker, Bernd (2006) Carbohydrates as scaffolds in drug discovery. ChemMedChem, 1 11: 1164-1194. doi:10.1002/cmdc.200600150

Author Meutermans, Wim
Le, Giang Thanh
Becker, Bernd
Title Carbohydrates as scaffolds in drug discovery
Journal name ChemMedChem   Check publisher's open access policy
ISSN 1860-7179
Publication date 2006-09-19
Sub-type Article (original research)
DOI 10.1002/cmdc.200600150
Volume 1
Issue 11
Start page 1164
End page 1194
Total pages 31
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Abstract Drug discovery has long suffered from the difficulty of having to place pharmacophoric groups in just the right spatial arrangement to elicit the desired biological response. Although some molecule classes have been discovered that seem to be privileged structures for at least some drug–receptor interactions, there remains the challenge to design and synthesize molecules with high specific affinity to pharmacologically important targets. With their high density of stereochemical information and their relative rigidity, carbohydrates provide excellent platforms upon which to display a number of substituents in a sterically defined way, hence offering the opportunity to harness their unique features for the drug-discovery process. This review highlights the progress that has been made in the development of carbohydrate scaffolds for drug discovery.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 91 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 99 times in Scopus Article | Citations
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Created: Fri, 23 Sep 2011, 10:48:38 EST by Bernd Becker on behalf of Institute for Molecular Bioscience