Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003-2006)

Lynch, Brigid M., Friedenreich, Christine M., Winkler, Elisabeth A.H., Healy, Genevie`ve N., Vallance, Jeff K., Eakin, Elizabeth G. and Owen, Neville (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003-2006). Breast Cancer Research and Treatment, 130 1: 183-194. doi:10.1007/s10549-011-1559-2


Author Lynch, Brigid M.
Friedenreich, Christine M.
Winkler, Elisabeth A.H.
Healy, Genevie`ve N.
Vallance, Jeff K.
Eakin, Elizabeth G.
Owen, Neville
Title Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003-2006)
Journal name Breast Cancer Research and Treatment   Check publisher's open access policy
ISSN 0167-6806
1573-7217
Publication date 2011-11
Sub-type Article (original research)
DOI 10.1007/s10549-011-1559-2
Volume 130
Issue 1
Start page 183
End page 194
Total pages 12
Place of publication New York, NY, United States
Publisher Springer New York LLC
Collection year 2012
Language eng
Abstract Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute additionally to this risk. We examined cross-sectional associations of objectively assessed physical activity and sedentary time with established biomarkers of breast cancer risk in a population-based sample of postmenopausal women. Accelerometer, anthropometric and laboratory data were available for 1,024 (n = 443 fasting) postmenopausal women in the U.S. National Health and Nutrition Examination Survey 2003–2006. Associations of quartiles of the accelerometer variables (moderate- to vigorous-intensity activity, light-intensity activity and sedentary time per day; average length of active and sedentary bouts) with the continuous biomarkers were assessed using linear regression models. Following adjustment for potential confounders, including sedentary time, moderate- to vigorous-intensity activity had significant (P < 0.05), inverse associations with all biomarker outcomes (body mass index, waist circumference, C-reactive protein, fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance). Light-intensity activity and sedentary time were significantly associated in fully adjusted models with all biomarkers except fasting glucose. Active bout length was associated with a smaller waist circumference and lower C-reactive protein levels, while sedentary bout length was associated with a higher BMI. The associations of objectively assessed moderate- to vigorous-intensity activity with breast cancer biomarkers are consistent with the established beneficial effects of self-reported exercise on breast cancer risk. Our findings further suggest that light-intensity activity may have a protective effect, and that sedentary time may independently contribute to breast cancer risk.
Keyword Breast cancer
Physical activity
Sedentary behavior
Biological markers
Postmenopausal women
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes online first

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
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Created: Fri, 23 Sep 2011, 10:10:27 EST by Geraldine Fitzgerald on behalf of School of Public Health