New perspectives on rodent models of advanced paternal age: Relevance to autism

Foldi, Claire J., Eyles, Darryl W., Flatscher-Bader, Traute, McGrath, John J. and Burne, Thomas H. J. (2011) New perspectives on rodent models of advanced paternal age: Relevance to autism. Frontiers in Behavioral Neuroscience, 5 32: 1-7. doi:10.3389/fnbeh.2011.00032

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Author Foldi, Claire J.
Eyles, Darryl W.
Flatscher-Bader, Traute
McGrath, John J.
Burne, Thomas H. J.
Title New perspectives on rodent models of advanced paternal age: Relevance to autism
Journal name Frontiers in Behavioral Neuroscience   Check publisher's open access policy
ISSN 1662-5153
Publication date 2011-06-23
Sub-type Article (original research)
DOI 10.3389/fnbeh.2011.00032
Open Access Status DOI
Volume 5
Issue 32
Start page 1
End page 7
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2012
Language eng
Abstract Offspring of older fathers have an increased risk of various adverse health outcomes, including autism and schizophrenia. With respect to biological mechanisms for this association, there are many more germline cell divisions in the life history of a sperm relative to that of an oocyte. This leads to more opportunities for copy error mutations in germ cells from older fathers. Evidence also suggests that epigenetic patterning in the sperm from older men is altered. Rodent models provide an experimental platform to examine the association between paternal age and brain development. Several rodent models of advanced paternal age (APA) have been published with relevance to intermediate phenotypes related to autism. All four published APA models vary in key features creating a lack of consistency with respect to behavioral phenotypes. A consideration of common phenotypes that emerge from these APA-related mouse models may be informative in the exploration of the molecular and neurobiological correlates of APA.
Keyword Advanced paternal age
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Thu, 22 Sep 2011, 14:00:48 EST by Dr Trudi Flatscher-bader on behalf of Queensland Brain Institute