'Benign' ovarian teratoma and N-methyl-D-aspartate receptor (NMDAR) encephalitis in a child

Frawley, Kieran J., Calvo-Garcia, Maria A., Krueger, Darcy A. and McMasters, Richard L. (2012) 'Benign' ovarian teratoma and N-methyl-D-aspartate receptor (NMDAR) encephalitis in a child. Pediatric Radiology, 42 1: 120-123. doi:10.1007/s00247-011-2111-6

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Author Frawley, Kieran J.
Calvo-Garcia, Maria A.
Krueger, Darcy A.
McMasters, Richard L.
Title 'Benign' ovarian teratoma and N-methyl-D-aspartate receptor (NMDAR) encephalitis in a child
Journal name Pediatric Radiology   Check publisher's open access policy
ISSN 0301-0449
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s00247-011-2111-6
Volume 42
Issue 1
Start page 120
End page 123
Total pages 4
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract N-methyl-D-aspartate receptor (NMDAR) encephalitis is a life-threatening paraneoplastic neuropsychiatric encephalitis that predominantly affects young women and has a strong association with ovarian teratomas. Removal of the ovarian teratomas improves the prognosis and decreases the risk of recurrence. We present an 11-year-old girl with NMDAR encephalitis with small bilateral teratomas not initially appreciated on abdominal CT or pelvic MRI. A 12-mm teratoma was identified in the right ovary and a 7-mm teratoma was identified in the left ovary on US follow-up at 5 months. Intraoperative sonography was used to localize the teratomas for excision. In NMDAR encephalitis, the ovarian teratomas can be very small, particularly in children, and easily missed on cross-sectional imaging. Awareness of the association of NMDAR encephalitis and ovarian teratomas will improve the diagnostic accuracy and imaging interpretation. Periodic sonography and MRI might be warranted in children if the initial study is negative.
Keyword Children
NMDAR encephalitis
Paraneoplastic encephalitis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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Created: Thu, 22 Sep 2011, 10:13:25 EST by Kieran Frawley on behalf of Medical Imaging - RBWH