Muscle Specific Kinase: Organiser of synaptic membrane domains

Ghazanfari, Nazanin, Fernandez, Kristine J., Murata, Yui, Morsch, Marco, Ngo, Shyuan T., Reddel, Stephen W., Noakes, Peter G. and Phillips, William D. (2011) Muscle Specific Kinase: Organiser of synaptic membrane domains. The International Journal of Biochemistry and Cell Biology, 43 3: 295-298. doi:10.1016/j.biocel.2010.10.008

Author Ghazanfari, Nazanin
Fernandez, Kristine J.
Murata, Yui
Morsch, Marco
Ngo, Shyuan T.
Reddel, Stephen W.
Noakes, Peter G.
Phillips, William D.
Title Muscle Specific Kinase: Organiser of synaptic membrane domains
Journal name The International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 0020-711X
Publication date 2011-03
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.biocel.2010.10.008
Volume 43
Issue 3
Start page 295
End page 298
Total pages 4
Place of publication East Park, Kidlington, Oxford, U.K.
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
Muscle Specific Kinase (MuSK) is a transmembrane tyrosine kinase vital for forming and maintaining the mammalian neuromuscular junction (NMJ: the synapse between motor nerve and skeletal muscle). MuSK expression switches on during skeletal muscle differentiation. MuSK then becomes restricted to the postsynaptic membrane of the NMJ, where it functions to cluster acetylcholine receptors (AChRs). The expression, activation and turnover of MuSK are each regulated by signals from the motor nerve terminal. MuSK forms the core of an emerging signalling complex that can be acutely activated by neural agrin (N-agrin), a heparin sulfate proteoglycan secreted from the nerve terminal. MuSK activation initiates complex intracellular signalling events that coordinate the local synthesis and assembly of synaptic proteins. The importance of MuSK as a synapse organiser is highlighted by cases of autoimmune myasthenia gravis in which MuSK autoantibodies can deplete MuSK from the postsynaptic membrane, leading to complete disassembly of the adult NMJ.
Keyword MuSK
Synapse formation
Tyrosine kinases
Receptor tyrosine kinase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 23 October 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 20 Sep 2011, 16:14:05 EST by Ms Shyuan Ngo on behalf of School of Biomedical Sciences