Grey matter injury in the hypoxic-ischemic neonate

Sullivan, Susan M. (2011). Grey matter injury in the hypoxic-ischemic neonate. In Andres Costa and Eugenio Villalba (Ed.), Horizons in neuroscience research (pp. 71-95) Hauppauge, NY, United States: Nova Science Publishers.

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Name Description MIMEType Size Downloads
Author Sullivan, Susan M.
Title of chapter Grey matter injury in the hypoxic-ischemic neonate
Title of book Horizons in neuroscience research
Place of Publication Hauppauge, NY, United States
Publisher Nova Science Publishers
Publication Year 2011
Sub-type Research book chapter (original research)
ISBN 9781613241714
Editor Andres Costa
Eugenio Villalba
Volume number 5
Chapter number 3
Start page 71
End page 95
Total pages 25
Total chapters 13
Collection year 2012
Language eng
Abstract/Summary The grey matter of the brain consists of large numbers of neuronal cell bodies and dendrites, along with blood vessels and glial cells such as astrocytes and microglia; and is responsible for processing and initiating responses to sensory or motor stimuli. Injury to grey matter can affect individuals of all ages as a consequence of head trauma, stroke and neurodegenerative diseases such as Alzheimer’s disease. In the neonate, hypoxia/ischemia (HI, a deficiency in oxygen availability or restriction in blood supply) is a common occurrence during parturition, arising as a consequence of complications such as placental abruption and umbilical cord compression. HI events can damage both grey and white matter and cause life-long consequences such as mental retardation, cerebral palsy, epilepsy and learning disabilities. This chapter will discuss grey matter injury in the HI neonate, detailing mechanisms of damage and the changes that occur in the major cells of grey matter, the neurons and astrocytes. Grey matter damage after an HI event develops over a period of days to weeks; therefore a therapeutic window exists for treatment or intervention. Current and future therapeutic strategies for HI neonates will be discussed with reference to reducing grey matter injury in the neonatal brain.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 20 Sep 2011, 16:07:07 EST by Dr Susan Sullivan on behalf of UQ Centre for Clinical Research