The epidemiology of invasive group A streptococcal disease in Victoria, Australia

O'Grady, Kerry-Ann F., Kelpie, Loraine, Andrews, Ross M., Curtis, Nigel, Nolan, Terence M., Selvaraj, Gowri, Passmore, Jonathan W., Oppedisano, Frances, Carnie, John A. and Carapetis, Jonathan R. (2007) The epidemiology of invasive group A streptococcal disease in Victoria, Australia. Medical Journal of Australia, 186 11: 565-569.

Author O'Grady, Kerry-Ann F.
Kelpie, Loraine
Andrews, Ross M.
Curtis, Nigel
Nolan, Terence M.
Selvaraj, Gowri
Passmore, Jonathan W.
Oppedisano, Frances
Carnie, John A.
Carapetis, Jonathan R.
Title The epidemiology of invasive group A streptococcal disease in Victoria, Australia
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2007-06-04
Sub-type Article (original research)
Volume 186
Issue 11
Start page 565
End page 569
Total pages 5
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing Company
Language eng
Formatted abstract
Objective: To estimate the incidence and severity of invasive group A streptococcal infection in Victoria, Australia.

Design: Prospective active surveillance study.

Setting: Public and private laboratories, hospitals and general practitioners throughout Victoria.

Patients: People in Victoria diagnosed with group A streptococcal disease notified to the surveillance system between 1 March 2002 and 31 August 2004.

Main outcome measure: Confirmed invasive group A streptococcal disease.

Results: We identified 333 confirmed cases: an average annualised incidence rate of 2.7 (95% CI, 2.3–3.2) per 100 000 population per year. Rates were highest in people aged 65 years and older and those younger than 5 years. The case-fatality rate was 7.8%. Streptococcal toxic shock syndrome occurred in 48 patients (14.4%), with a case-fatality rate of 23%. Thirty cases of necrotising fasciitis were reported; five (17%) of these patients died. Type 1 (23%) was the most frequently identified emm sequence type in all age groups. All tested isolates were susceptible to penicillin and clindamycin. Two isolates (4%) were resistant to erythromycin.

Conclusion: The incidence of invasive group A streptococcal disease in temperate Australia is greater than previously appreciated and warrants greater public health attention, including its designation as a notifiable disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 20 Sep 2011, 15:04:23 EST by Dr Kerry-ann O'grady on behalf of Child Health Research Centre