Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein

Skwarczynski, Mariusz, Ahmad Fuaad, Abdullah A. H., Rustanti, Lina, Ziora, Zyta M., Aqil, Mohammed, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2011) Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein. Drug Delivery Letters, 1 1: 2-8. doi:10.2174/2210304X11101010002

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Author Skwarczynski, Mariusz
Ahmad Fuaad, Abdullah A. H.
Rustanti, Lina
Ziora, Zyta M.
Aqil, Mohammed
Batzloff, Michael R.
Good, Michael F.
Toth, Istvan
Title Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein
Journal name Drug Delivery Letters   Check publisher's open access policy
ISSN 2210-3031
2210-304X
Publication date 2011-03-12
Sub-type Article (original research)
DOI 10.2174/2210304X11101010002
Volume 1
Issue 1
Start page 2
End page 8
Total pages 7
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Abstract Copper catalysed azide alkyne Huisgen cycloaddition (click) reaction assisted conjugation of the multiple copy of conserve epitope (J14) derived from Group A Streptococcal M-protein to LCP core induced desired α-helical conformation of the epitope. The constructs were able to self assemble into large nanoparticles under aqueous conditions. Immunological assessment of these particles demonstrated their capacity to elicit high-titer systemic IgG antibodies against the epitope without help of adjuvant. The LCP systems incorporating the epitope via its N- or C-termini did not elicit significantly different immune responses.
Keyword Epitope orientation
Group A streptococcus
Infectious disease
Lipid core peptide
Nanoparticles
Self-adjuvanting
Lipopeptide vaccine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 21 Sep 2011, 00:13:58 EST by Dr Mariusz Skwarczynski on behalf of School of Chemistry & Molecular Biosciences