Changes in excitability of corticomotor inputs to the trunk muscles during experimentally-induced acute low back pain

Tsao, H., Tucker, K. J. and Hodges, P. W. (2011) Changes in excitability of corticomotor inputs to the trunk muscles during experimentally-induced acute low back pain. Neuroscience, 181 127-133. doi:10.1016/j.neuroscience.2011.02.033


Author Tsao, H.
Tucker, K. J.
Hodges, P. W.
Title Changes in excitability of corticomotor inputs to the trunk muscles during experimentally-induced acute low back pain
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
1873-7544
Publication date 2011-05-05
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2011.02.033
Volume 181
Start page 127
End page 133
Total pages 7
Place of publication East Park, Kidlington, Oxford, U.K.
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
Acute low back pain (LBP) is associated with differential changes in motor coordination of deep and superficial trunk muscles. Whether this is related to differential changes in excitability of descending corticomotor inputs remains unclear and was investigated in nine healthy individuals. Fine-wire i.m. electrodes were inserted bilaterally into deep (transversus abdominis (TrA)) and superficial abdominal muscles (obliquus externus abdominis (OE)), and surface electrodes were placed bilaterally over obliquus internus abdominis (OI), rectus abdominis (RA) and lumbar erector spinae (LES) muscles. Corticomotor excitability was assessed as amplitude of motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) at a range of stimulator intensities, at rest and during voluntary abdominal contractions. Pain was induced by injection of hypertonic saline into interspinous ligaments of the lumbar spine. Corticomotor excitability was examined before, during and after the induction of LBP. During pain, amplitude of TrA MEPs to contralateral cortical stimulation was reduced, whereas amplitudes of OE and LES MEPs contralateral and ipsilateral to the stimulated cortex were increased. The findings highlight differential changes in excitability of corticomotor inputs to trunk muscles during acute LBP. Further work is required to reveal whether such changes involve spinal and/or supraspinal centres and their consequence for spine control.

Highlights: ▶Experimental back pain changes corticomotor excitability of trunk muscles. ▶Reduced corticomotor excitability to deep trunk muscle with pain. ▶Increased corticomotor excitability to superficial trunk muscles with pain. ▶Findings suggest differential corticomotor changes to trunk muscles during acute back pain.
Keyword Low back pain
Motor cortex
Corticospinal excitability
Trunk muscles
Experimental pain
Transcranial magnetic stimulation
Motor-evoked-potentials
Abdominal-muscles
Lumbar spine
Postural control
Voluntary
Cortex
Recruitment
Inhibition
Activation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Cognitive, Behavioral, and Systems Neuroscience".

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Tue, 20 Sep 2011, 13:03:38 EST by Ms Kylie Tucker on behalf of School of Health & Rehabilitation Sciences