PX-FERM proteins: A link between endosomal trafficking and signaling?

Ghai, Rajesh and Collins, Brett M. (2011) PX-FERM proteins: A link between endosomal trafficking and signaling?. Small GTPases, 2 5: .

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Author Ghai, Rajesh
Collins, Brett M.
Title PX-FERM proteins: A link between endosomal trafficking and signaling?
Journal name Small GTPases   Check publisher's open access policy
ISSN 2154-1248
Publication date 2011-09
Sub-type Article (original research)
Volume 2
Issue 5
Total pages 5
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Collection year 2012
Language eng
Abstract Endosomes are the primary organelle where decisions are made as to whether endocytosed proteins will be sorted into degradative trafficking pathways or recycled back to the plasma membrane. This balance between cellular uptake and recycling regulates the plasma membrane composition and is therefore critical for many cellular processes such as nutrient uptake, neuronal transmission and cell migration.1 In addition to its well-known role in membrane trafficking, the endosome is increasingly being recognized as a critical cellular domain for regulated cell signaling. We recently showed that several proteins that regulate endosomal recycling, SNX17, SNX27 and SNX31 are structurally and functionally related.2 These proteins use an unusual FERM domain to bind specific endosomal cargo molecules, and most interestingly, we also found that these proteins use the same FERM domain to associate with the activated Ras small GTPase. Here we speculate on the potential dual role of the PX-FERM proteins in endosomal transport and as scaffolds that may be involved in endosomal Ras signaling processes.
Keyword Ras
Sorting nexin
PX domain
FERM domain
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes "Extra view"

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
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Created: Tue, 20 Sep 2011, 12:39:53 EST by Brett Collins on behalf of School of Biomedical Sciences