Melanocortin 1 receptor and risk of cutaneous melanoma: A meta-analysis and estimates of population burden

Williams, Patricia F., Olsen, Catherine M., Hayward, Nicholas K. and Whiteman, David C. (2011) Melanocortin 1 receptor and risk of cutaneous melanoma: A meta-analysis and estimates of population burden. International Journal of Cancer, 129 7: 1730-1740. doi:10.1002/ijc.25804

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Author Williams, Patricia F.
Olsen, Catherine M.
Hayward, Nicholas K.
Whiteman, David C.
Title Melanocortin 1 receptor and risk of cutaneous melanoma: A meta-analysis and estimates of population burden
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1002/ijc.25804
Volume 129
Issue 7
Start page 1730
End page 1740
Total pages 11
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
Polymorphisms in the melanocortin 1 receptor (MC1R) gene have been associated with increased risks of melanoma, but different approaches to study design, analysis, and reporting have hindered comparisons of findings. We aimed to harmonize the published data by conducting a systematic review and meta-analysis of MC1R variants and thereby estimate relative risks and population attributable fractions (PAFs). We identified 20 analytic studies reporting on 25 populations, which presented quantitative data on melanoma risks associated with any of nine MC1R variants. We separately pooled estimates of risk per person and risk per chromosome using a random effects model. Red hair color (RHC) variants had the highest risk of melanoma [summary odds ratios (OR) 2.44, 95% confidence interval (CI) 1.72–3.45, PAF 16.8% CI 0.119–0.202], but non-RHC variants were also associated with increased risk (summary OR 1.29, 95% CI 1.10–1.51, PAF 7.4% CI 0.030–0.112). The summary risk of melanoma associated with individual variants ranged from OR 2.40 for R142H to 1.18 for V60L, although significant heterogeneity was evident for most variants. PAFs ranged from 0.55% for I155T to 6.28% for R151C. Our findings suggest the nine most common MC1R variants make a sizeable contribution to the burden of melanoma. Melanoma research would be greatly assisted by standardized classifications for MC1R variants and consistent reporting conventions. More compatible and comparable research would allow for more powerful data that could be clinically applied to predict melanoma risk.
Keyword Melanoma
Attributable fraction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 1 APR 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 44 times in Scopus Article | Citations
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Created: Mon, 19 Sep 2011, 13:34:25 EST by Matthew Lamb on behalf of School of Medicine