Annelid Distal-less/Dlx duplications reveal varied post-duplication fates

McDougall, Carmel, Korchagina, Natalia, Tobin, Jonathan L. and Ferrier, David E. K. (2011) Annelid Distal-less/Dlx duplications reveal varied post-duplication fates. BMC Evolutionary Biology, 11 241: 1-16.


Author McDougall, Carmel
Korchagina, Natalia
Tobin, Jonathan L.
Ferrier, David E. K.
Title Annelid Distal-less/Dlx duplications reveal varied post-duplication fates
Journal name BMC Evolutionary Biology   Check publisher's open access policy
ISSN 1471-2148
Publication date 2011-08-16
Sub-type Article (original research)
DOI 10.1186/1471-2148-11-241
Volume 11
Issue 241
Start page 1
End page 16
Total pages 16
Place of publication London, U.K.
Publisher BioMed Central
Collection year 2012
Language eng
Formatted abstract Background: Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. While the genomic arrangement and function of these genes is well known in vertebrates and arthropods, information about Dlx genes in other organisms is scarce. We investigate the presence of Dlx genes in several annelid species and examine Dlx gene expression in the polychaete Pomatoceros lamarckii.

Results: Two Dlx genes are present in P. lamarckii, Capitella teleta and Helobdella robusta. The C. teleta Dlx genes are closely linked in an inverted tail-to-tail orientation, reminiscent of the arrangement of vertebrate Dlx pairs, and gene conversion appears to have had a role in their evolution. The H. robusta Dlx genes, however, are not on the same genomic scaffold and display divergent sequences, while, if the P. lamarckii genes are linked in a tail-to-tail orientation they are a minimum of 41 kilobases apart and show no sign of gene conversion. No expression in P. lamarckii appendage development has been observed, which conflicts with the supposed conserved role of these genes in animal appendage development. These Dlx duplications do not appear to be annelid-wide, as the polychaete Platynereis dumerilii likely possesses only one Dlx gene.

Conclusions: On the basis of the currently accepted annelid phylogeny, we hypothesise that one Dlx duplication occurred in the annelid lineage after the divergence of P. dumerilii from the other lineages and these duplicates then had varied evolutionary fates in different species. We also propose that the ancestral role of Dlx genes is not related to appendage development.
Keyword Class homeobox genes
Concerted evolution
Nematostella-vectensis
Expression patterns
Nervous-system
Sea-anemone
Limb development
Common origin
Hox proteins
DNA-binding
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
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