IgE responsiveness to Dermatophagoides farinae in West Highland white terrier dogs is associated with region on CFA35

Roque, Joana Barros, O'Leary, Caroline Ann, Duffy, David Lorenzo, Kyaw-Tanner, Myat, Latter, Melanie, Mason, Kenneth, Vogelnest, Linda and Shipstone, Michael (2011). IgE responsiveness to Dermatophagoides farinae in West Highland white terrier dogs is associated with region on CFA35. In: Symposium Issue: Fifth International Conference on Advances in Canine and Feline Genomics and Inherited Diseases. Fifth International Conference on Advances in Canine and Feline Genomics and Inherited Diseases, Baltimore, MA, U.S.A., (S74-S80). 22-25 September 2010. doi:10.1093/jhered/esr054


Author Roque, Joana Barros
O'Leary, Caroline Ann
Duffy, David Lorenzo
Kyaw-Tanner, Myat
Latter, Melanie
Mason, Kenneth
Vogelnest, Linda
Shipstone, Michael
Title of paper IgE responsiveness to Dermatophagoides farinae in West Highland white terrier dogs is associated with region on CFA35
Formatted title
IgE responsiveness to Dermatophagoides farinae in West Highland white terrier dogs is associated with region on CFA35
Conference name Fifth International Conference on Advances in Canine and Feline Genomics and Inherited Diseases
Conference location Baltimore, MA, U.S.A.
Conference dates 22-25 September 2010
Proceedings title Symposium Issue: Fifth International Conference on Advances in Canine and Feline Genomics and Inherited Diseases   Check publisher's open access policy
Journal name Journal of Heredity   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Oxford University Press
Publication Year 2011
Year available 2010
Sub-type Fully published paper
DOI 10.1093/jhered/esr054
ISSN 0022-1503
1465-7333
Volume 102
Issue Supp. 1
Start page S74
End page S80
Total pages 7
Collection year 2012
Language eng
Formatted Abstract/Summary
Immunoglobulin E (IgE)-mediated hypersensitivity against environmental allergens, commonly including Dermatophagoides farinae, is associated with atopic diseases in both humans and dogs. We have recently identified a family of clinically healthy West Highland white terriers (WHWTs) with high-serum D. farinae-IgE levels. In this study, we investigated the genetic mechanism controlling IgE responsiveness in dogs by performing a genome-wide association study (GWAS) using the Affymetrix V2 Dog SNP array in 31 high-IgE and 24 low-IgE responder WHWTs. A gene-dropping simulation method, using SIB-PAIR software, showed significant allelic association between serum D. farinae–specific IgE levels and a 2.3-Mb area on CFA35 (best empirical P = 1 × 10−5). A nearby candidate gene, CD83, encodes a protein which has important immunological functions in antigen presentation and regulation of humoral immune responses. We sequenced this gene in 2 high-IgE responders and 2 low-IgE responders and identified an intronic polymorphic repeat sequence with a predicted functional effect, but the association was insufficient to explain the GWAS association signal in this population (P = 1 × 10−3). Further studies are necessary to investigate the significance of these findings for IgE responsiveness and atopic disease in the dog.
Keyword Atopy
Canine
GWAS
House dust mite
IgE
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Symposium Articles".

Document type: Conference Paper
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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