Can Wolbachia be used to control malaria?

Walker, Thomas and Moreira, Luciano Andrade (2011) Can Wolbachia be used to control malaria?. Memorias Do Instituto Oswaldo Cruz, 106 212-217. doi:10.1590/S0074-02762011000900026


Author Walker, Thomas
Moreira, Luciano Andrade
Title Can Wolbachia be used to control malaria?
Journal name Memorias Do Instituto Oswaldo Cruz   Check publisher's open access policy
ISSN 0074-0276
1678-8060
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1590/S0074-02762011000900026
Open Access Status DOI
Volume 106
Start page 212
End page 217
Total pages 6
Place of publication Rio de Janeiro, Brazil
Publisher Instituto Oswaldo Cruz
Collection year 2012
Language eng
Abstract Malaria is a mosquito-borne infectious disease caused by Plasmodium parasites transmitted by the infectious bite of Anopheles mosquitoes. Vector control of malaria has predominantly focused on targeting the adult mosquito through insecticides and bed nets. However, current vector control methods are often not sustainable for long periods so alternative methods are needed. A novel biocontrol approach for mosquito-borne diseases has recently been proposed, it uses maternally inherited endosymbiotic Wolbachia bacteria transinfected into mosquitoes in order to interfere with pathogen transmission. Transinfected Wolbachia strains in Aedes aegypti mosquitoes, the primary vector of dengue fever, directly inhibit pathogen replication, including Plasmodium gallinaceum, and also affect mosquito reproduction to allow Wolbachia to spread through mosquito populations. In addition, transient Wolbachia infections in Anopheles gambiae significantly reduce Plasmodium levels. Here we review the prospects of using a Wolbachiabased approach to reduce human malaria transmission through transinfection of Anopheles mosquitoes.
Keyword Malaria
Anopheles
Plasmodium
Wolbachia
Transinfection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
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