The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Lin, Quan, Wei, Wei, Coelho, Carlos M., Li, Xiang, Baker-Andresen, Dannay, Dudley, Kevin, Ratnu, Vikram S., Boskovic, Zoran, Kobor, Michael S., Sun, Yi E. and Bredy, Timothy W. (2011) The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nature Neuroscience, 14 9: 1115-1117. doi:10.1038/nn.2891

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Author Lin, Quan
Wei, Wei
Coelho, Carlos M.
Li, Xiang
Baker-Andresen, Dannay
Dudley, Kevin
Ratnu, Vikram S.
Boskovic, Zoran
Kobor, Michael S.
Sun, Yi E.
Bredy, Timothy W.
Title The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1038/nn.2891
Open Access Status File (Author Post-print)
Volume 14
Issue 9
Start page 1115
End page 1117
Total pages 3
Place of publication United States
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory. © 2011 Nature America, Inc. All rights reserved.
Keyword Calcineurin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 60 times in Scopus Article | Citations
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