Slice-timing effects and their correction in functional MRI

Sladky, Ronald, Friston, Karl J., Trostl, Jasmin, Cunnington, Ross, Moser, Ewald and Windischberger, Christian (2011) Slice-timing effects and their correction in functional MRI. Neuroimage, 58 2: 588-594. doi:10.1016/j.neuroimage.2011.06.078


Author Sladky, Ronald
Friston, Karl J.
Trostl, Jasmin
Cunnington, Ross
Moser, Ewald
Windischberger, Christian
Title Slice-timing effects and their correction in functional MRI
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2011.06.078
Volume 58
Issue 2
Start page 588
End page 594
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2012
Language eng
Abstract Exact timing is essential for functional MRI data analysis. Datasets are commonly measured using repeated 2D imaging methods, resulting in a temporal offset between slices. To compensate for this timing difference, slice-timing correction (i.e. temporal data interpolation) has been used as an fMRI pre-processing step for more than fifteen years. However, there has been an ongoing debate about the effectiveness and applicability of this method. This paper presents the first elaborated analysis of the impact of the slice-timing effect on simulated data for different fMRI paradigms and measurement parameters, taking into account data noise and smoothing effects. Here we show, depending on repetition time and paradigm design, slice-timing effects can significantly impair fMRI results and slice-timing correction methods can successfully compensate for these effects and therefore increase the robustness of the data analysis. In addition, our results from simulated data were supported by empirical in vivo datasets. Our findings suggest that slice-timing correction should be included in the fMRI pre-processing pipeline.
Keyword Functional MRI
Pre-processing
Analysis
Slice-timing correction
FMRI data
Latency
Parameters
Model
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Psychology Publications
 
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