Discovery and applications of naturally occurring cyclic peptides

Craik, D., Poth, A., Colgrave, M., Akcan, M., Oku, B., Chan, A. and Daly, N. (2011). Discovery and applications of naturally occurring cyclic peptides. In: K. Hüsnü Can Başer, 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Antalya, Turkey, (1231-1231). 4-9 September 2011. doi:10.1055/s-0031-1282086


Author Craik, D.
Poth, A.
Colgrave, M.
Akcan, M.
Oku, B.
Chan, A.
Daly, N.
Title of paper Discovery and applications of naturally occurring cyclic peptides
Conference name 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
Conference location Antalya, Turkey
Conference dates 4-9 September 2011
Proceedings title 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research   Check publisher's open access policy
Journal name Planta Medica   Check publisher's open access policy
Place of Publication Stuttgart, Germany
Publisher Georg Thieme Verlag
Publication Year 2011
Sub-type Published abstract
DOI 10.1055/s-0031-1282086
ISSN 0032-0943
1439-0221
Editor K. Hüsnü Can Başer
Volume 77
Issue 12
Start page 1231
End page 1231
Total pages 1
Language eng
Formatted Abstract/Summary
Over recent years more than 200 examples of ribosomally synthesized head-to-tail cyclised proteins have been discovered in bacteria, plants and animals. The cyclotides are the largest family of these circular proteins and have applications in drug design and agriculture. They occur in plants from the Violaceae (violet), Rubiaceae (coffee) and Cucurbitaceae (cucurbit) families and have a diverse range of biological activities, including uterotonic, anti-HIV, and insecticidal activities, the latter suggesting that their natural function is in plant defence. Individual plants express suites of 10-100 cyclotides. Cyclotides typically comprise ˜30 amino acids, and incorporate three disulfide bonds arranged in a cystine knot topology. The combination of this knotted structure with a circular backbone renders the cyclotides impervious to enzymatic breakdown and makes them exceptionally stable. This presentation will describe the discovery of cyclotides in plants, their structural characterization, evolutionary relationships and their applications in drug design. Their stability and compact structure makes them an attractive protein framework onto which bioactive peptide epitopes can be grafted to stabilize them.
Keyword Cyclic peptides
Cyclotides
Drug design
NMR
Protein structure
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication date: August 2011. Published under "Lectures" as Abstract L8.

Document type: Conference Paper
Collections: Non HERDC
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