Calorie restriction and stroke

Manzanero, Silvia, Gelderblom, Mathias, Magnus, Tim and Arumugam, Thiruma V. (2011) Calorie restriction and stroke. Experimental and Translational Stroke Medicine, 3 8.1-8.35. doi:10.1186/2040-7378-3-8

Author Manzanero, Silvia
Gelderblom, Mathias
Magnus, Tim
Arumugam, Thiruma V.
Title Calorie restriction and stroke
Journal name Experimental and Translational Stroke Medicine   Check publisher's open access policy
ISSN 2040-7378
Publication date 2011-09-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/2040-7378-3-8
Open Access Status DOI
Volume 3
Start page 8.1
End page 8.35
Total pages 35
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2012
Language eng
Abstract Stroke, a major cause of disability and mortality in the elderly, occurs when a cerebral blood vessel is occluded or ruptured, resulting in ischemic damage and death of brain cells. The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. In animal models, dietary energy restriction, by daily calorie reduction (CR) or intermittent fasting (IF), extends lifespan and decreases the development of age-related diseases. Dietary energy restriction may also benefit neurons, as suggested by experimental evidence showing that CR and IF protect neurons against degeneration in animal models. Recent findings by our group and others suggest the possibility that dietary energy restriction may protect against stroke induced brain injury, in part by inducing the expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF); protein chaperones, including heat shock protein 70 (Hsp70) and glucose regulated protein 78 (GRP78); antioxidant enzymes, such as superoxide dismutases (SOD) and heme oxygenase-1 (HO-1), silent information regulator T1 (SIRT1), uncoupling proteins and anti-inflammatory cytokines. This article discusses the protective mechanisms activated by dietary energy restriction in ischemic stroke.
Keyword Calorie restriction
Intermittent fasting
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Biomedical Sciences Publications
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Created: Mon, 12 Sep 2011, 20:27:10 EST by Dr Thiruma V Arumugam on behalf of School of Biomedical Sciences