Left atrial size-Another Differentiator for Cardiac Amyloidosis

Fitzgerald, Benjamin T., Scalia, Gregory M., Cain, Peter A., Garcia, Mario J. and Thomas, James D. (2011) Left atrial size-Another Differentiator for Cardiac Amyloidosis. Heart Lung and Circulation, 20 9: 574-578. doi:10.1016/j.hlc.2011.06.002

Author Fitzgerald, Benjamin T.
Scalia, Gregory M.
Cain, Peter A.
Garcia, Mario J.
Thomas, James D.
Title Left atrial size-Another Differentiator for Cardiac Amyloidosis
Journal name Heart Lung and Circulation   Check publisher's open access policy
ISSN 1443-9506
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1016/j.hlc.2011.06.002
Volume 20
Issue 9
Start page 574
End page 578
Total pages 5
Place of publication Chatswood, N.S.W., Australia
Publisher Elsevier Australia
Collection year 2012
Language eng
Formatted abstract
Background: The “sparkled” echocardiographic appearance of amyloid has become less visually obvious in the era of harmonic imaging. Significantly dilated atria in the setting of a normal sized ventricle may be another easy visual marker for cardiac amyloidosis.
Methods: A retrospective analysis of echocardiograms of patients with biopsy-proven cardiac amyloid compared with patients with hypertension was conducted. There were 36 patients in each group, and they were matched for left ventricular wall thickness, as well as age and sex.
Results: Patients with cardiac amyloid had significantly larger atria than the group with hypertension (left atrial areas 29 cm2 versus 19 cm2, p < 0.001, AUC 0.84, volumes 100 cm3 versus 55 cm3, p < 0.001, AUC 0.915). A volume of 69 cm3 produced a specificity and sensitivity of 85% for amyloidosis.
Conclusions: Atrial dilatation can be used as a visual marker for cardiac amyloidosis. This may be a simple visual method to differentiate this infiltrative cardiomyopathy from left ventricular hypertrophy.
Keyword Amyloidosis
Heart atria
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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