Biolabeling hematopoietic system cells using near-infrared fluorescent gold nanoclusters

Huang, Xin, Luo, Yi, Li, Zhen, Li, Buyi, Zhang, Hui, Li, Luo, Majeed, Irfan, Zou, Ping and Tan, Bien (2011) Biolabeling hematopoietic system cells using near-infrared fluorescent gold nanoclusters. The Journal of Physical Chemistry C, 115 34: 16753-16763. doi:10.1021/jp202612p


Author Huang, Xin
Luo, Yi
Li, Zhen
Li, Buyi
Zhang, Hui
Li, Luo
Majeed, Irfan
Zou, Ping
Tan, Bien
Title Biolabeling hematopoietic system cells using near-infrared fluorescent gold nanoclusters
Journal name The Journal of Physical Chemistry C   Check publisher's open access policy
ISSN 1932-7447
1932-7455
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1021/jp202612p
Volume 115
Issue 34
Start page 16753
End page 16763
Total pages 11
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2012
Language eng
Formatted abstract
Highly bright fluorescent gold nanoclusters (Au NCs) have been prepared by one-step reduction of aqueous precursor solution in the presence of multidentate thioether-terminated poly(methacrylic acid) (PTMP-PMAA). The fluorescence quantum yield of the resultant Au NCs is 4.8% higher than that of the similarly sized Au NCs prepared by the etching method (1.8-4.0%). These Au NCs show excellent photostability and have been successfully applied to label the hematopoietic cells first. The results show that Au NCs were endocytosed by the cancer cells significantly more than the normal cells, in comparison with control experiments labeled with fluorescent quantum dots (CdTe). The cytotoxicity experiments demonstrate the excellent biocompatibility of Au NCs, proven by a relatively lower cytotoxicity than CdTe. These robust near-infrared Au NCs show great potential in biolabeling, tracking, and imaging of other cells and diseases, especially in the diagnosis and treatment of chronic myeloid leukemia. © 2011 American Chemical Society.
Keyword Quantum Dots
Highly Fluorescent
Polymer Ligands
Cancer-Cells
Nanoparticles
Size
Cytotoxicity
Nanocrystals
Molecules
Clusters
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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