Identifying preliminary domains to detect and measure rheumatoid arthritis flares: Report of the OMERACT 10 RA flare workshop

Bingham, Clifton O., Alten, Rieke, Bartlett, Susan J., Bykerk, Vivian P., Brooks, Peter M., Choy, Ernest, Christensen, Robin, Furst, Daniel E., Hewlett, Sarah E., Leong, Amye, May, James E., Montie, Pam, Pohl, Christof, Sanderson, Tessa C., Strand, Vibeke, Woodworth, Thasia and OMERACT RA Flare Definition Working Group (2011) Identifying preliminary domains to detect and measure rheumatoid arthritis flares: Report of the OMERACT 10 RA flare workshop. Journal of Rheumatology, 38 8: 1751-1758. doi:10.3899/jrheum.110401

Author Bingham, Clifton O.
Alten, Rieke
Bartlett, Susan J.
Bykerk, Vivian P.
Brooks, Peter M.
Choy, Ernest
Christensen, Robin
Furst, Daniel E.
Hewlett, Sarah E.
Leong, Amye
May, James E.
Montie, Pam
Pohl, Christof
Sanderson, Tessa C.
Strand, Vibeke
Woodworth, Thasia
OMERACT RA Flare Definition Working Group
Title Identifying preliminary domains to detect and measure rheumatoid arthritis flares: Report of the OMERACT 10 RA flare workshop
Journal name Journal of Rheumatology   Check publisher's open access policy
ISSN 0315-162X
Publication date 2011-08
Sub-type Article (original research)
DOI 10.3899/jrheum.110401
Volume 38
Issue 8
Start page 1751
End page 1758
Total pages 8
Place of publication Toronto, ON, Canada
Publisher Journal of Rheumatology Publishing
Collection year 2012
Language eng
Formatted abstract
Background. While disease flares in rheumatoid arthritis (RA) are a recognized aspect of the disease process, there is limited formative research to describe them.
Methods. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA Flare Definition Working Group is conducting an international research project to understand the specific characteristics and impact of episodic disease worsening, or “flare,” so that outcome measures can be developed or modified to reflect this uncommonly measured, but very real and sometimes disabling RA disease feature. Patient research partners provided critical insights into the multidimensional nature of flare. The perspectives of patients and healthcare and research professionals are being integrated to ensure that any outcome measurement to detect flares fulfills the first OMERACT criteria of Truth. Through an iterative data-driven Delphi process, a preliminary list of key domains has been identified to evaluate flare. 

Results. At OMERACT 10, consensus was achieved identifying features of flare in addition to the existing core set for RA, including fatigue, stiffness, symptom persistence, systemic features, and participation. Patient self-report of flare was identified as a component of the research agenda needed to establish criterion validity for a flare definition; this can be used in prospective studies to further evaluate the Discrimination and Feasibility components of the OMERACT filter for a flare outcome measure. 

Conclusion. Our work to date has provided better understanding of key aspects of the RA disease process as episodic, potentially disabling disease worsening even when a patient is in low disease activity. It also highlights the importance of developing ways to enhance communication between patients and clinicians and improve the ability to achieve “tight control” of disease. 
Keyword Disease Activity
Rheumatoid Arthritis
Outcome Assessment
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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