Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Hoffmann, A. A., Montgomery, B. L., Popovici, J., Iturbe-Ormaetxe, I., Johnson, P. H., Muzzi, F., Greenfield, M., Durkan, M., Leong, Y. S., Dong, Y., Cook, H., Axford, J., Callahan, A. G., Kenny, N., Omodei, C., McGraw, E. A., Ryan, P. A., Ritchie, S. A., Turelli, M. and O'Neill, S. L. (2011) Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature, 476 7361: 454-459. doi:10.1038/nature10356


Author Hoffmann, A. A.
Montgomery, B. L.
Popovici, J.
Iturbe-Ormaetxe, I.
Johnson, P. H.
Muzzi, F.
Greenfield, M.
Durkan, M.
Leong, Y. S.
Dong, Y.
Cook, H.
Axford, J.
Callahan, A. G.
Kenny, N.
Omodei, C.
McGraw, E. A.
Ryan, P. A.
Ritchie, S. A.
Turelli, M.
O'Neill, S. L.
Title Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2011-08-01
Sub-type Article (original research)
DOI 10.1038/nature10356
Volume 476
Issue 7361
Start page 454
End page 459
Total pages 6
Place of publication United Kingdom
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility. When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan. Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster, successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency <30% that must be exceeded for invasion. These findings demonstrate that Wolbachia-based strategies can be deployed as a practical approach to dengue suppression with potential for area-wide implementation. © 2011 Macmillan Publishers Limited. All Rights Reserved.
Keyword Life-Shortening Wolbachia
Cytoplasmic Incompatibility
Genetic-Control
Aegypti
Australia
Mosquitos
Drosophila
Dispersal
Infection
Replacement
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 396 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 426 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 12 Sep 2011, 07:20:09 EST by System User on behalf of School of Biological Sciences